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INO80 Antibody (CL488-68064) in Flow
1X10^6 PC-12 cells were intracellularly stained with 0.8 µg CoraLite® Plus 488 Anti-Human INO80 (CL488-68064, Clone:1F11C5) (red), or 0.8 µg Control Antibody. Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-68064
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F11C5
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: KQVTVYRLIC KGTIEERILQ RAKEKSEIQR MVISGGNFKP DTLKPKEVVS LLLDDEELEK KLRLRQEEKR QQEETNRVKE RKRKREKYAE KKKKEDELDG KRRKEGVNLV IPFVPSADNS NLSADGDDSF ISVDSAMPSP FSEISISSEL HTGSIPLDES SSDMLVIVDD PASSAPQSRA TNSPASITGS VSDTVNGISI QEMPAAGRGH SARSRGRPKG SGSTAKGAGK GRSRKSTAGS AAAMAGAKAG AAAASAAAYA AYGYNVSKGI SASSPLQTSL VRPAGLADFG PSSASSPLSS PLSKGNNVPG NPKNLHMTSS LAPDSLVRKQ GKGTNPSGGR
Target Information
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chromatin-remodeling ATPase INO80; DNA helicase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; INO80 complex homolog 1; INO80 complex subunit A; INO80 homolog; putative DNA helicase INO80 complex homolog 1; yeast INO80-like protein
Gene Aliases: 2310079N15Rik; 4632409L19Rik; hINO80; INO80; INO80A; INOC1; KIAA1259; RGD1310969
UniProt ID: (Human) Q9ULG1, (Mouse) Q6ZPV2
Entrez Gene ID: (Human) 54617, (Mouse) 68142, (Rat) 296084
mitotic sister chromatid segregation
double-strand break repair via homologous recombination
DNA repair
double-strand break repair
DNA recombination
chromatin remodeling
cellular response to DNA damage stimulus
cell cycle
mitotic nuclear division
positive regulation of nuclear cell cycle DNA replication
positive regulation of cell growth
DNA duplex unwinding
cellular response to UV
positive regulation of transcription from RNA polymerase II promoter
spindle assembly
cell division
UV-damage excision repair
cellular response to ionizing radiation
regulation of G1/S transition of mitotic cell cycle
transcription, DNA-templated
biological_process
metabolic process
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