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INPP5B Polyclonal Antibody

INPP5B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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INPP5B Antibody (15141-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using (Product # 15141-1-AP) (INPP5B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

15141-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

INPP5B Fusion Protein Ag7315 (1-309 aa encoded by BC058932)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDQSVAIQE TLAEGEYCVI AVQGVLCEGD SRQSRLLGLV RYRLEHGGQE HALFLYTHRR MAITGDDVSL DQIVPVSRDF TLEEVSPDGE LYILGSDVTV QLDTAELSLV FQLPFGSQTR MFLHEVARAC PGFDSATRDP EFLWLSRYRC AELELEMPTP RGCNSALVTW PGYATIGGGG SNFDGLRPNG KGVPMDQSSR GQDKPESLQP RQNKSKSEIT DMVRSSTITV SDKAHILSMQ KFGLRDTIVK SHLLQKEEDY TYIQNFRFFA GTYNVNGQSP KECLRLWLSN GIQAPDVYCV GFQELDLSKE (1-309 aa encoded by BC058932)

Target Information

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Decreased INPP5B expression predicts poor prognosis in lung adenocarcinoma.

Cancer cell international

Deng J,Lin X,Li Q,Cai XY,Wu LW,Wang W,Zhang B,Li YL,Hu J,Lin NM

Sat May 14 00:00:00 UTC 2022

Integrated application of transcriptome and metabolomics reveals potential therapeutic targets for the polarization of atherosclerotic macrophages.

Biochimica et biophysica acta. Molecular basis of disease

Shen L,Li H,Chen W,Su Y,Yu J,Chen M,Shu G,Qiao E,Guo X,Xu M,Xia S,Zhao Z,Lu C,Ji J

Thu Dec 01 00:00:00 UTC 2022

Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model.

Journal of the American Society of Nephrology : JASN

Gliozzi ML,Espiritu EB,Shipman KE,Rbaibi Y,Long KR,Roy N,Duncan AW,Lazzara MJ,Hukriede NA,Baty CJ,Weisz OA

Wed Jan 01 00:00:00 UTC 2020

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.

PloS one

Luo N,Kumar A,Conwell M,Weinreb RN,Anderson R,Sun Y

Fri Oct 20 00:00:00 UTC 2017

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.

PloS one

Luo N,Kumar A,Conwell M,Weinreb RN,Anderson R,Sun Y

Fri Oct 20 00:00:00 UTC 2017

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.

PloS one

Luo N,Kumar A,Conwell M,Weinreb RN,Anderson R,Sun Y

Fri Oct 20 00:00:00 UTC 2017

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.

PloS one

Luo N,Kumar A,Conwell M,Weinreb RN,Anderson R,Sun Y

Fri Oct 20 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: 5PTase; 75 kDa inositol polyphosphate-5-phosphatase; Inositol polyphosphate-5-phosphatase B; inositol polyphosphate-5-phosphatase, 75kDa; MGC65156; MGC71303; Phosphoinositide 5-phosphatase; RP11-109P14.7; Type II inositol 1,4,5-trisphosphate 5-phosphatase; type II inositol-1

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Gene Aliases: 5PTase; AW260155; INPP5B; INPP5P; OCRL2

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UniProt ID: (Human) P32019, (Mouse) Q8K337

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Entrez Gene ID: (Human) 3633, (Mouse) 16330, (Rat) 362590

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Function(s)

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GTPase activator activity protein binding metal ion binding inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity molecular_function

Process(es)

in utero embryonic development signal transduction spermatogenesis sperm motility positive regulation of GTPase activity inositol phosphate metabolic process phosphatidylinositol dephosphorylation regulation of small GTPase mediated signal transduction regulation of protein processing biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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INPP5B Polyclonal Antibody

INPP5B Antibody (15141-1-AP) in IHC (P)

Product Details

15141-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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