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Invitrogen
INPP5B Polyclonal Antibody
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INPP5B Antibody (PA5-100575) in IHC (P)
Immunohistochemistry analysis of INPP5B in rat testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with INPP5B polyclonal antibody (Product # PA5-100575) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-100575
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human INPP5B(Accession P32019), corresponding to amino acid residues R243-K293.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850083
Product Specific Information
Antibody detects endogenous levels of total INPP5B.
Target Information
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5PTase; 75 kDa inositol polyphosphate-5-phosphatase; Inositol polyphosphate-5-phosphatase B; inositol polyphosphate-5-phosphatase, 75kDa; MGC65156; MGC71303; Phosphoinositide 5-phosphatase; RP11-109P14.7; Type II inositol 1,4,5-trisphosphate 5-phosphatase; type II inositol-1
Gene Aliases: 5PTase; AW260155; INPP5B; INPP5P; OCRL2
UniProt ID: (Human) P32019, (Mouse) Q8K337
Entrez Gene ID: (Human) 3633, (Mouse) 16330, (Rat) 362590
in utero embryonic development
signal transduction
spermatogenesis
sperm motility
positive regulation of GTPase activity
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
regulation of small GTPase mediated signal transduction
regulation of protein processing
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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