Abnova

INPP5K Monoclonal Antibody (3B4)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

H00051763-M09

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

3B4

Immunogen

INPP5K (AAH04362, 1 a.a. approximately 448 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Product may be used with Western Blot (Tissue lysate).

Immunogen sequence: MSSRKLSGPK GRRLSIHVVT WNVASAAPPL DLSDLLQLNN RNLNPDIYVI GLQELNSGII SLLSDAAFND SWSSFLMDVL SPLSFIKVSH VRMQGILLLV FAKYQHLPYI QILSTKSTPT GLFGYWGNKG GVNICLKLYG YYVSIINCHL PPHISNNYQR LEHFDRILEM QNCEGRDIPN ILDHDLIIWF GDMNFRIEDF GLRFVRESIK NRCYGGLWEK DQLSIAKKHD PLLREFQEGR LLFPPTYKFD RNSNDYDTSE KKRKPAWTDR ILWRLKRQPC AGPDTPIPPA SHFSLSLRGY SSHMTYGISD HKPVSGTFDL ELKPLVSAPL IVLMPEDLWT VENDMMVSYS STSDFPSSPW DWIGLYKVGL RDVNDYVSYA WVGDSKVSCS DNLNQVYIDI SNIPTTEDEF LLCYYSNSLR SVVGISRPFQ IPPGSLREDP LGEAQPQI

Target Information

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Inositol polyphosphate 5-phosphatase K; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase

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Gene Aliases: INPP5K; PPS; SKIP

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UniProt ID: (Human) Q9BT40

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Entrez Gene ID: (Human) 51763

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Function(s)
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity vasopressin receptor activity protein binding inositol bisphosphate phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol trisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity lipid phosphatase activity inositol trisphosphate phosphatase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Process(es)
in utero embryonic development negative regulation of protein phosphorylation regulation of glycogen biosynthetic process negative regulation of protein kinase activity phosphatidylinositol biosynthetic process G-protein coupled receptor signaling pathway negative regulation of peptidyl-threonine phosphorylation negative regulation of glucose transport dephosphorylation actin cytoskeleton organization cellular response to insulin stimulus cellular response to hormone stimulus negative regulation of peptidyl-serine phosphorylation negative regulation of dephosphorylation positive regulation of urine volume glucose homeostasis negative regulation of MAP kinase activity negative regulation by host of viral transcription negative regulation of glycogen biosynthetic process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of insulin receptor signaling pathway inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation negative regulation of stress fiber assembly negative regulation of protein kinase B signaling negative regulation of calcium ion transport cellular response to cAMP cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus protein targeting to plasma membrane negative regulation of protein targeting to membrane ruffle assembly negative regulation of glycogen (starch) synthase activity positive regulation of renal water transport
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