Proteintech

INSR Polyclonal Antibody

FIGURE: 1 / 6

INSR Antibody (20433-1-AP) in WB

HT-1080 cells were subjected to SDS PAGE followed by western blot with 20433-1-AP (INSR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

INSR Antibody in Immunoprecipitation (IP)

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Product Details

20433-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

Assay-dependent

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Dot blot (DB)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

INSR Fusion Protein Ag13922 (980-1382 aa encoded by BC117172)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RKRQPDGPL GPLYASSNPE YLSASDVFPC SVYVPDEWEV SREKITLLRE LGQGSFGMVY EGNARDIIKG EAETRVAVKT VNESASLRER IEFLNEASVM KGFTCHHVVR LLGVVSKGQP TLVVMELMAH GDLKSYLRSL RPEAENNPGR PPPTLQEMIQ MAAEIADGMA YLNAKKFVHR DLAARNCMVA HDFTVKIGDF GMTRDIYETD YYRKGGKGLL PVRWMAPESL KDGVFTTSSD MWSFGVVLWE ITSLAEQPYQ GLSNEQVLKF VMDGGYLDQP DNCPERVTDL MRMCWQFNPK MRPTFLEIVN LLKDDLHPSF PEVSFFHSEE NKAPESEELE MEFEDMENVP LDRSSHCQRE EAGGRDGGSS LGFKRSYEEH IPYTHMNGGK KNGRILTLPR SNPS (980-1382 aa encoded by BC117172)

Target Information

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The effect of PINK1/Parkin pathway on glucose homeostasis imbalance induced by tacrolimus in mouse livers.

Heliyon

Li Z,Xiang J,Mei S,Wu Y,Xu Y

Sat Apr 01 00:00:00 UTC 2023

High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia (Oreochromis niloticus).

Marine life science & technology

Li RX,Chen LY,Limbu SM,Qian YC,Zhou WH,Chen LQ,Luo Y,Qiao F,Zhang ML,Du ZY

Wed Feb 01 00:00:00 UTC 2023

Dependence of glucose transport on autophagy and GAPDH activity.

Brain research

Craven RJ,Frazier HN,Thibault O

Tue Feb 01 00:00:00 UTC 2022

Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.

Food & function

Huang H,Chen J,Hu X,Chen Y,Xie J,Ao T,Wang H,Xie J,Yu Q

Mon Mar 07 00:00:00 UTC 2022

Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice.

Bioscience, biotechnology, and biochemistry

Hara T,Toyama H,Ohata Y,Ikeuchi T,Nakamura S,Joh T,Ohtsubo K

Thu Oct 20 00:00:00 UTC 2022

Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.

Environmental health perspectives

Raber J,Perez R,Torres ERS,Krenik D,Boutros S,Patel E,Chlebowski AC,Torres ER,Perveen Z,Penn A,Paulsen DB,Bartlett MG,Jia E,Holden S,Hall R,Morré J,Wong C,Ho E,Choi J,Stevens JF,Noël A,Bobe G,Kisby G

Sat May 01 00:00:00 UTC 2021

Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease.

CNS neuroscience & therapeutics

Wang H,Lv JJ,Zhao Y,Wei HL,Zhang TJ,Yang HJ,Chen ZN,Jiang JL

Thu May 13 00:00:00 UTC 2021

Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.

Pediatric research

Huang F,Zhu P,Wang J,Chen J,Lin W

Fri Jan 01 00:00:00 UTC 2021

Systematic investigation of the pharmacological mechanism for renal protection by the leaves of Eucommia ulmoides Oliver using UPLC-Q-TOF/MS combined with network pharmacology analysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Huang Q,Zhang F,Liu S,Jiang Y,Ouyang D

Sun Aug 01 00:00:00 UTC 2021

The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients in fish.

Fish physiology and biochemistry

Han SL,Liu Y,Limbu SM,Chen LQ,Zhang ML,Du ZY

Mon Feb 01 00:00:00 UTC 2021

Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism.

Frontiers in pharmacology

Bai Y,Mo K,Wang G,Chen W,Zhang W,Guo Y,Sun Z

Tue Oct 05 00:00:00 UTC 2021

Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism.

Frontiers in pharmacology

Bai Y,Mo K,Wang G,Chen W,Zhang W,Guo Y,Sun Z

Tue Oct 05 00:00:00 UTC 2021

Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism.

Frontiers in pharmacology

Bai Y,Mo K,Wang G,Chen W,Zhang W,Guo Y,Sun Z

Tue Oct 05 00:00:00 UTC 2021

Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism.

Frontiers in pharmacology

Bai Y,Mo K,Wang G,Chen W,Zhang W,Guo Y,Sun Z

Tue Oct 05 00:00:00 UTC 2021

Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.

Nutrients

Lin L,Zeng L,Liu A,Yuan D,Peng Y,Zhang S,Li Y,Chen J,Xiao W,Gong Z

Wed Nov 17 00:00:00 UTC 2021

Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Xu T,Xu L,Meng P,Ma X,Yang X,Zhou Y,Feng M

Thu Oct 01 00:00:00 UTC 2020

l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.

Food & function

Lin L,Zeng L,Liu A,Peng Y,Yuan D,Zhang S,Li Y,Chen J,Xiao W,Gong Z

Wed Feb 26 00:00:00 UTC 2020

RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness.

Carcinogenesis

Huang G,Song C,Wang N,Qin T,Sui S,Obr A,Zeng L,Wood TL,Leroith D,Li M,Wu Y

Thu Sep 24 00:00:00 UTC 2020

Acid Loading Unmasks Glucose Homeostatic Instability in Proximal-Tubule-Targeted Insulin/Insulin-Like-Growth-Factor-1 Receptor Dual Knockout Mice.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Aljaylani A,Fluitt M,Piselli A,Shepard BD,Tiwari S,Ecelbarger CM

Sat Jul 18 00:00:00 UTC 2020

Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish.

The Journal of physiology

Li LY,Lv HB,Jiang ZY,Qiao F,Chen LQ,Zhang ML,Du ZY

Thu Oct 01 00:00:00 UTC 2020

Inhibited autophagy impairs systemic nutrient metabolism in Nile tilapia.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Han SL,Wang J,Zhang YX,Qiao F,Chen LQ,Zhang ML,Du ZY

Tue Oct 01 00:00:00 UTC 2019

MiR-128 regulation of glucose metabolism and cell proliferation in triple-negative breast cancer.

The British journal of surgery

Xiao M,Lou C,Xiao H,Yang Y,Cai X,Li C,Jia S,Huang Y

Mon Jan 01 00:00:00 UTC 2018

MiR-128 regulation of glucose metabolism and cell proliferation in triple-negative breast cancer.

The British journal of surgery

Xiao M,Lou C,Xiao H,Yang Y,Cai X,Li C,Jia S,Huang Y

Mon Jan 01 00:00:00 UTC 2018

NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.

Scientific reports

Yang S,Liu M,Chen Y,Ma C,Liu L,Zhao B,Wang Y,Li X,Zhu Y,Gao X,Kong D,Duan Y,Han J,Yang X

Thu Jun 14 00:00:00 UTC 2018

NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.

Scientific reports

Yang S,Liu M,Chen Y,Ma C,Liu L,Zhao B,Wang Y,Li X,Zhu Y,Gao X,Kong D,Duan Y,Han J,Yang X

Thu Jun 14 00:00:00 UTC 2018

NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.

Scientific reports

Yang S,Liu M,Chen Y,Ma C,Liu L,Zhao B,Wang Y,Li X,Zhu Y,Gao X,Kong D,Duan Y,Han J,Yang X

Thu Jun 14 00:00:00 UTC 2018

NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.

Scientific reports

Yang S,Liu M,Chen Y,Ma C,Liu L,Zhao B,Wang Y,Li X,Zhu Y,Gao X,Kong D,Duan Y,Han J,Yang X

Thu Jun 14 00:00:00 UTC 2018

Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ.

Toxicology and applied pharmacology

Zhang W,Shen XY,Zhang WW,Chen H,Xu WP,Wei W

Wed Feb 01 00:00:00 UTC 2017

Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ.

Toxicology and applied pharmacology

Zhang W,Shen XY,Zhang WW,Chen H,Xu WP,Wei W

Wed Feb 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: CD 220; CD220; CD220 antigen; CD220 beta; CD221; HHF 5; IGF-I receptor; Insulin receptor; IR; IR 1; IR beta; IR-1; IR1

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Gene Aliases: CD220; HHF5; INSR

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UniProt ID: (Human) P06213

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Entrez Gene ID: (Human) 3643

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Function(s)

protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding protein binding ATP binding GTP binding protein phosphatase binding lipoic acid binding insulin-like growth factor I binding insulin-like growth factor II binding protein complex binding 3-phosphoinositide-dependent protein kinase binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding PTB domain binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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INSR Polyclonal Antibody

INSR Antibody (20433-1-AP) in WB

Product Details

20433-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

Dot blot (DB)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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