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Invitrogen
INSRR Recombinant Rabbit Monoclonal Antibody (JM22-38)
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Product Details
MA5-32731
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM22-38
Immunogen
Synthetic peptide within Human Insulin Receptor R aa 12-61
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2810008
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
INSRR, insulin receptor-related receptor, is a member of the insulin receptor (IR) family. INSRR does not bind insulin-like molecules, but is similar to INSR in tyrosine kinase activity. Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Insulin receptor-related protein; insulin receptor-related receptor; IR-related receptor; IRR
Gene Aliases: INSRR; IRR; Sirr
UniProt ID: (Human) P14616, (Mouse) Q9WTL4, (Rat) Q64716
Entrez Gene ID: (Human) 3645, (Mouse) 23920, (Rat) 60663
transmembrane receptor protein tyrosine kinase activity
ATP binding
phosphatidylinositol 3-kinase binding
insulin receptor substrate binding
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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