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Proteintech
INTU Polyclonal Antibody
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Product Details
24914-1-AP
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
INTU Fusion Protein Ag19313 (1-354 aa encoded by BC130611)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASVASCDS RPSSDELPGD PSSQEEDEDY DFEDRVSDSG SYSSASSDYD DLEPEWLDSV QKNGELFYLE LSEDEEESLL PETPTVNHVR FSENEIIIED DYKERKKYEP KLKQFTKILR RKRLLPKRCN KKNSNDNGPV SILKHQSNQK TGVIVQQRYK DVNVYVNPKK LTVIKAKEQL KLLEVLVGII HQTKWSWRRT GKQGDGERLV VHGLLPGGSA MKSGQVLIGD VLVAVNDVDV TTENIERVLS CIPGPMQVKL TFENAYDVKR ETSHPRQKKT QSNTSDLVKL LWGEEVEGIQ QSGLNTPHII MYLTLQLDSE TSKEEQEILY HYPMSEASQK LKSVRGIFLT LCDML (1-354 aa encoded by BC130611)
Target Information
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of inturned; Inturned planar cell polarity effector homolog; PDZ domain containing 6; PDZ domain-containing protein 6; Protein inturned
Gene Aliases: 9230116I04Rik; 9430087H23Rik; INT; INTU; KIAA1284; mKIAA1284; PDZD6; PDZK6
UniProt ID: (Human) Q9ULD6, (Mouse) Q059U7
Entrez Gene ID: (Human) 27152, (Mouse) 380614
nervous system development
regulation of smoothened signaling pathway
negative regulation of keratinocyte proliferation
spinal cord dorsal/ventral patterning
neural tube development
keratinocyte differentiation
regulation of ossification
hair follicle morphogenesis
cilium assembly
embryonic digit morphogenesis
positive regulation of smoothened signaling pathway
negative regulation of cell division
limb development
motile primary cilium assembly
multicellular organism development
cell projection organization
cilium morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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