Product References
Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.
Neuron
Coffin SL,Durham MA,Nitschke L,Xhako E,Brown AM,Revelli JP,Villavicencio Gonzalez E,Lin T,Handler HP,Dai Y,Trostle AJ,Wan YW,Liu Z,Sillitoe RV,Orr HT,Zoghbi HY
PA1-901 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to underscore the complexity of mechanisms driving cellular vulnerability in SCA1.
Wed Feb 15 00:00:00 UTC 2023
Diospyros lotus leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation.
Experimental and therapeutic medicine
Shin JY,Cho BO,Park JH,Kang ES,Kim YS,Jang SI
PA1-901 was used in Western Blotting to suggest that Diospyros lotus leaf extract and myricetin can be used as oral therapeutic agents for the treatment and management of pruritus.
Sat Jul 01 00:00:00 UTC 2023
Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects.
Disease models & mechanisms
Liang JH,Alevy J,Akhanov V,Seo R,Massey CA,Jiang D,Zhou J,Sillitoe RV,Noebels JL,Samuel MA
PA1-901 was used in Immunocytochemistry-immunoflourescence to define a new model for KCTD7-associated epilepsy and identify Kctd7 as a modulator of neuron survival and excitability linked to microvascular alterations in vulnerable regions.
Thu Sep 01 00:00:00 UTC 2022
iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2.
Nature communications
Dulloo I,Atakpa-Adaji P,Yeh YC,Levet C,Muliyil S,Lu F,Taylor CW,Freeman M
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Western Blot
Thu Mar 10 00:00:00 UTC 2022
Alpinumisoflavone Disrupts Endoplasmic Reticulum and Mitochondria Leading to Apoptosis in Human Ovarian Cancer.
Pharmaceutics
Hong T,Ham J,Song G,Lim W
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Western Blot
Fri Mar 04 00:00:00 UTC 2022
Dual antibody strategy for high-resolution imaging of murine Purkinje cells and their dendrites across multiple layers.
STAR protocols
Botta S,Chemiakine A,Gennarino VA
PA1-901 was used in Immunohistochemistry-immunofluorescence to describe a two-antibody strategy which was developed to study Purkinje cell morphology in mice.
Fri Jun 17 00:00:00 UTC 2022
Dual antibody strategy for high-resolution imaging of murine Purkinje cells and their dendrites across multiple layers.
STAR protocols
Botta S,Chemiakine A,Gennarino VA
PA1-901 was used in Immunohistochemistry-immunofluorescence to describe a two-antibody strategy which was developed to study Purkinje cell morphology in mice.
Fri Jun 17 00:00:00 UTC 2022
Itpr1 regulates the formation of anterior eye segment tissues derived from neural crest cells.
Development (Cambridge, England)
Kinoshita A,Ohyama K,Tanimura S,Matsuda K,Kishino T,Negishi Y,Asahina N,Shiraishi H,Hosoki K,Tomiwa K,Ishihara N,Mishima H,Mori R,Nakashima M,Saitoh S,Yoshiura KI
PA1-901 was used in Western Blot to reveal that the 218-aa isoform regulated the directionality of actin fibers and the intensity of focal adhesion. The isoform might control the nuclear entry of transcriptional regulators, such as YAP. It is possible that ITPR1 regulates both AES differentiation and muscle contraction in the iris.
Sun Aug 15 00:00:00 UTC 2021
Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer.
Journal of cellular physiology
Bae H,Lee JY,Song J,Song G,Lim W
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Western Blot
Mon Feb 01 00:00:00 UTC 2021
FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis.
Nature communications
Wang C,Dai X,Wu S,Xu W,Song P,Huang K,Zou MH
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Western Blot
Mon May 10 00:00:00 UTC 2021
β2-adrenergic receptor regulates ER-mitochondria contacts.
Scientific reports
Lim Y,Cho IT,Rennke HG,Cho G
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Western Blot
Tue Nov 02 00:00:00 UTC 2021
Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration.
Science advances
Kwak YD,Shaw TI,Downing SM,Tewari A,Jin H,Li Y,Dumitrache LC,Katyal S,Khodakhah K,Russell HR,McKinnon PJ
PA1-901 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Flow Cytometry to reveal the pathogenic basis of DNA damage in the nervous system and suggest chromatin conformation as a feature in directing genome instability-associated neuropathology.
Fri Dec 17 00:00:00 UTC 2021
Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration.
Science advances
Kwak YD,Shaw TI,Downing SM,Tewari A,Jin H,Li Y,Dumitrache LC,Katyal S,Khodakhah K,Russell HR,McKinnon PJ
PA1-901 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Flow Cytometry to reveal the pathogenic basis of DNA damage in the nervous system and suggest chromatin conformation as a feature in directing genome instability-associated neuropathology.
Fri Dec 17 00:00:00 UTC 2021
Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration.
Science advances
Kwak YD,Shaw TI,Downing SM,Tewari A,Jin H,Li Y,Dumitrache LC,Katyal S,Khodakhah K,Russell HR,McKinnon PJ
PA1-901 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Flow Cytometry to reveal the pathogenic basis of DNA damage in the nervous system and suggest chromatin conformation as a feature in directing genome instability-associated neuropathology.
Fri Dec 17 00:00:00 UTC 2021
Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
Pharmaceutics
Bae H,Song G,Lim W
PA1-901 was used in Western Blotting to investigate the effects of stigmasterol on proapoptotic signals, mitochondrial function, reactive oxygen species production, and the cytosolic and mitochondrial calcium levels in human ovarian cancer cells, to understand the mechanisms underlying the effects of stigmasterol on ovarian cancer cells.
Thu May 28 00:00:00 UTC 2020
Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
Pharmaceutics
Bae H,Song G,Lim W
PA1-901 was used in Western Blotting to investigate the effects of stigmasterol on proapoptotic signals, mitochondrial function, reactive oxygen species production, and the cytosolic and mitochondrial calcium levels in human ovarian cancer cells, to understand the mechanisms underlying the effects of stigmasterol on ovarian cancer cells.
Thu May 28 00:00:00 UTC 2020
Fucoidan Derived from Fucus vesiculosus Inhibits the Development of Human Ovarian Cancer via the Disturbance of Calcium Homeostasis, Endoplasmic Reticulum Stress, and Angiogenesis.
Marine drugs
Bae H,Lee JY,Yang C,Song G,Lim W
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Western Blot
Thu Jan 09 00:00:00 UTC 2020
XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response.
Cell reports
Fink EE,Moparthy S,Bagati A,Bianchi-Smiraglia A,Lipchick BC,Wolff DW,Roll MV,Wang J,Liu S,Bakin AV,Kandel ES,Lee AH,Nikiforov MA
PA1-901 was used in Western Blot to identify a role for XBP1s in cytotoxic unfolded protein response and provide insights into mechanisms of life-or-death decisions in cells under endoplasmic reticulum stress.
Tue Oct 02 00:00:00 UTC 2018
VEGF-A inhibits agonist-mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells.
The Journal of physiology
Ye X,Beckett T,Bagher P,Garland CJ,Dora KA
PA1-901 was used in Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to demonstrate that VEGF-A acts via VEGF receptor-2 (R2) to inhibit both endothelial cell (EC) Ca2+ release and the associated EDH vasodilatation mediated by intermediate conductance Ca2+ -activated K+ (IKCa ) channels.
Wed Aug 01 00:00:00 UTC 2018
Antibodies to inositol 1,4,5-triphosphate receptor 1 in patients with cerebellar disease.
Neurology(R) neuroimmunology & neuroinflammation
Fouka P,Alexopoulos H,Chatzi I,Dedos SG,Samiotaki M,Panayotou G,Politis P,Tzioufas A,Dalakas MC
PA1901 was used in immunohistochemistry - frozen section and western blot to discuss newly identified autoantibodies associated with cerebellar disorders
Sun Jan 01 00:00:00 UTC 2017
Antibodies to inositol 1,4,5-triphosphate receptor 1 in patients with cerebellar disease.
Neurology(R) neuroimmunology & neuroinflammation
Fouka P,Alexopoulos H,Chatzi I,Dedos SG,Samiotaki M,Panayotou G,Politis P,Tzioufas A,Dalakas MC
PA1901 was used in immunohistochemistry - frozen section and western blot to discuss newly identified autoantibodies associated with cerebellar disorders
Sun Jan 01 00:00:00 UTC 2017
Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles.
Science signaling
Garland CJ,Bagher P,Powell C,Ye X,Lemmey HAL,Borysova L,Dora KA
PA1-901 was used in Immunocytochemistry-immunoflourescence to report that agonists that stimulate vascular smooth muscle depolarization provide Ca2+ to endothelial cells to activate a feedback circuit that protects tissue blood flow.
Tue Jul 04 00:00:00 UTC 2017
An optimized surgical approach for obtaining stable extracellular single-unit recordings from the cerebellum of head-fixed behaving mice.
Journal of neuroscience methods
White JJ,Lin T,Brown AM,Arancillo M,Lackey EP,Stay TL,Sillitoe RV
PA1-901 was used in immunohistochemistry - paraffin section to discuss potential technical problems while performing vivo electrophysiological recordings
Tue Mar 15 00:00:00 UTC 2016
Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.
Cell
Gennarino VA,Singh RK,White JJ,De Maio A,Han K,Kim JY,Jafar-Nejad P,di Ronza A,Kang H,Sayegh LS,Cooper TA,Orr HT,Sillitoe RV,Zoghbi HY
PA1-901 was used in immunocytochemistry to elucidate how post-translational modification of ATAXIN1 levels contributes to spinocerebellar ataxia type 1.
Thu Mar 12 00:00:00 UTC 2015
Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.
Nature medicine
Arruda AP,Pers BM,Parlakgül G,Güney E,Inouye K,Hotamisligil GS
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Western Blot
Mon Dec 01 00:00:00 UTC 2014
Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex.
Proceedings of the National Academy of Sciences of the United States of America
Fredericks GJ,Hoffmann FW,Rose AH,Osterheld HJ,Hess FM,Mercier F,Hoffmann PR
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Immunoprecipitation
Tue Nov 18 00:00:00 UTC 2014
TGFβ1 downregulates neurite outgrowth, expression of Ca2+ transporters, and mitochondrial dynamics of in vitro cerebellar granule cells.
Neuroreport
Jaskova K,Pavlovicova M,Cagalinec M,Lacinova L,Jurkovicova D
PA1-901 was used in western blot to study changes in cerebellar granular cell neurite outgrowth, calcium transporters, and mitochondrial biology in response to TGF-beta1
Wed Mar 26 00:00:00 UTC 2014
Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats.
American journal of physiology. Heart and circulatory physiology
Linde CI,Karashima E,Raina H,Zulian A,Wier WG,Hamlyn JM,Ferrari P,Blaustein MP,Golovina VA
PA1-901 was used in western blot to investigate the arterial smooth muscle calcium signaling and vascular functions in Milan hypertensive rats
Wed Feb 01 00:00:00 UTC 2012
Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis.
PloS one
Boncompagni S,Thomas M,Lopez JR,Allen PD,Yuan Q,Kranias EG,Franzini-Armstrong C,Perez CF
Published figure using IP3 Receptor 1 polyclonal antibody (Product # PA1-901) in Western Blot
Tue Nov 13 00:00:00 UTC 2012
A novel postsynaptic mechanism for heterosynaptic sharing of short-term plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Reissner KJ,Pu L,Schaffhausen JH,Boyle HD,Smith IF,Parker I,Carew TJ
PA1-901 was used in western blot to evaluate the role of calcium signalling in heterosynaptic plasticity
Wed Jun 30 00:00:00 UTC 2010
Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R.
Journal of molecular and cellular cardiology
Zhang K,Heidrich FM,DeGray B,Boehmerle W,Ehrlich BE
PA1-901 was used in western blot to investigate the effect of taxol on calcium signaling and calcium oscillation
Mon Nov 01 00:00:00 UTC 2010
Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells.
Journal of neuroscience research
Tao O,Shimazaki T,Okada Y,Naka H,Kohda K,Yuzaki M,Mizusawa H,Okano H
PA1-901 was used in immunocytochemistry to investigate the differentiation into cerebellar Purkinje cells from mouse embryonic stem cells
Mon Feb 01 00:00:00 UTC 2010
Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+.
The Journal of biological chemistry
Eltit JM,Feng W,Lopez JR,Padilla IT,Pessah IN,Molinski TF,Fruen BR,Allen PD,Perez CF
PA1-901 was used in western blot to investigate the importance of triadins in the regulation of resting cytoplasmic calcium
Fri Dec 03 00:00:00 UTC 2010
Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry.
Molecular biology of the cell
Cheshenko N,Liu W,Satlin LM,Herold BC
PA1-901 was used in immunocytochemistry to study the role of calcium in herpes simplex viruses entry.
Wed Aug 01 00:00:00 UTC 2007
Mini-dystrophin expression down-regulates overactivation of G protein-mediated IP3 signaling pathway in dystrophin-deficient muscle cells.
The Journal of general physiology
Balghi H,Sebille S,Constantin B,Patri S,Thoreau V,Mondin L,Mok E,Kitzis A,Raymond G,Cognard C
PA1-901 was used in immunocytochemistry and western blot to demonstrate the existence of a potential relationship between mini-dystrophin and SR calcium release
Wed Feb 01 00:00:00 UTC 2006
Mini-dystrophin expression down-regulates overactivation of G protein-mediated IP3 signaling pathway in dystrophin-deficient muscle cells.
The Journal of general physiology
Balghi H,Sebille S,Constantin B,Patri S,Thoreau V,Mondin L,Mok E,Kitzis A,Raymond G,Cognard C
PA1-901 was used in immunocytochemistry and western blot to demonstrate the existence of a potential relationship between mini-dystrophin and SR calcium release
Wed Feb 01 00:00:00 UTC 2006
Mini-dystrophin expression down-regulates IP3-mediated calcium release events in resting dystrophin-deficient muscle cells.
The Journal of general physiology
Balghi H,Sebille S,Mondin L,Cantereau A,Constantin B,Raymond G,Cognard C
PA1-901 was used in immunocytochemistry and western blot to study how dystrophin affects IP3-mediaed calcium signaling pathway in resting myotubes
Tue Aug 01 00:00:00 UTC 2006
Plasma and intracellular membrane inositol 1,4,5-trisphosphate receptors mediate the Ca(2+) increase associated with the ATP-induced increase in ciliary beat frequency.
American journal of physiology. Cell physiology
Barrera NP,Morales B,Villalón M
PA1-901 was used in immunocytochemistry to study the regulation of ciliary beat frequency
Fri Oct 01 00:00:00 UTC 2004
Individual subtypes of enteroendocrine cells in the mouse small intestine exhibit unique patterns of inositol 1,4,5-trisphosphate receptor expression.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Wang S,Liu J,Li L,Wice BM
PA1-901 was used in immunohistochemistry to investigate the patterns of inositol 1,4,5-trisphosphate receptor expression in individual subtypes of enteroendocrine cells in the mouse small intestine
Thu Jan 01 00:00:00 UTC 2004
Individual subtypes of enteroendocrine cells in the mouse small intestine exhibit unique patterns of inositol 1,4,5-trisphosphate receptor expression.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Wang S,Liu J,Li L,Wice BM
PA1-901 was used in immunohistochemistry to investigate the patterns of inositol 1,4,5-trisphosphate receptor expression in individual subtypes of enteroendocrine cells in the mouse small intestine
Thu Jan 01 00:00:00 UTC 2004
IP3 receptors and associated Ca2+ signals localize to satellite cells and to components of the neuromuscular junction in skeletal muscle.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Powell JA,Molgó J,Adams DS,Colasante C,Williams A,Bohlen M,Jaimovich E
PA1-901 was used in immunocytochemistry to demonstrate the effect of electrical activity on IP3-associated calcium signals.
Wed Sep 10 00:00:00 UTC 2003
ET-1 activates Ca2+ sparks in PASMC: local Ca2+ signaling between inositol trisphosphate and ryanodine receptors.
American journal of physiology. Lung cellular and molecular physiology
Zhang WM,Yip KP,Lin MJ,Shimoda LA,Li WH,Sham JS
PA1-901 was used in immunohistochemistry to suggest that ET-1 activation of calcium sparks is mediated via the ETA receptor-PLC-IP3 pathway
Mon Sep 01 00:00:00 UTC 2003
Type-specific inositol 1,4,5-trisphosphate receptor localization in the vomeronasal organ and its interaction with a transient receptor potential channel, TRPC2.
Journal of neurochemistry
Brann JH,Dennis JC,Morrison EE,Fadool DA
PA1-901 was used in immunohistochemistry to investigate the localization and role of inositol 1,4,5-trisphosphate receptor in the vomeronasal organ
Sun Dec 01 00:00:00 UTC 2002
Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction.
BMC neuroscience
Clapp TR,Stone LM,Margolskee RF,Kinnamon SC
PA1-901 was used in immunocytochemistry to study the role of type III IP3 receptor (IP3R3) in bitter taste transduction
Wed Apr 16 00:00:00 UTC 2003
Inhibition of type I and III IP(3)Rs by TGF-beta is associated with impaired calcium release in mesangial cells.
American journal of physiology. Renal physiology
Sharma K,Mc Gowan TA,Wang L,Madesh M,Kaspar V,Szalai G,Thomas AP,Hajnóczky G
PA1-901 was used in western blot to study the mechanism for the inhibitory effect of TGF-beta on inositol 1,4,5-trisphosphate receptors in mesangial cells.
Thu Jun 01 00:00:00 UTC 2000
