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          • Primary Antibodies ›
          • IP3 Receptor 2 Antibodies

          Invitrogen

          IP3 Receptor 2 Polyclonal Antibody

          View all (11) IP3 Receptor 2 antibodies

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          Cite IP3 Receptor 2 Polyclonal Antibody

          • Antibody Testing Data (9)
          IP3 Receptor 2 Antibody in Immunocytochemistry (ICC/IF)
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          IP3 Receptor 2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 9

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          IP3 Receptor 2 Antibody (PA5-141118) in ICC/IF

          Immunocytochemistry analysis of ITPR2 in HepG2 cells (green). Samples were incubated in ITPR2 Polyclonal antibody (Product # PA5-141118). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          IP3 Receptor 2 Antibody in Immunocytochemistry (ICC/IF)
          IP3 Receptor 2 Antibody in Immunocytochemistry (ICC/IF)
          IP3 Receptor 2 Antibody in Immunocytochemistry (ICC/IF)
          IP3 Receptor 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          IP3 Receptor 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          IP3 Receptor 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          IP3 Receptor 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          IP3 Receptor 2 Antibody in Flow Cytometry (Flow)
          IP3 Receptor 2 Antibody in Dot Blot (DB)

          Product Details

          PA5-141118

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:100
          -

          Flow Cytometry (Flow)

          1:50-1:100
          -

          Dot blot (DB)

          1:2,000-1:5,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant protein within human ITPR2 aa 1100-1450.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol, 0.2% BSA

          Contains

          0.05% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2932570

          Target Information

          Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to IP3R, IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. IP3R type I (IP3R-I) has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II is found predominantly in the brain. IP3R-III is known to be expressed in pancreatic islets, kidney, and the gastrointestinal tract.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor 5; inositol 1,4,5-triphosphate receptor, type 2; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate type V receptor; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2; inositol triphosphate receptor type 2; inositol trisphosphate receptor type 2; insP3R2; IP3 receptor; IP3 receptor isoform 2; IP3R; IP3R 2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor

          View more View less

          Gene Aliases: AI649341; ANHD; CFAP48; InsP3R-2; InsP3R-5; INSP3R2; IP3R2; ITPR2; Itpr5

          View more View less

          UniProt ID: (Human) Q14571, (Mouse) Q9Z329, (Rat) P29995

          View more View less

          Entrez Gene ID: (Human) 3709, (Mouse) 16439, (Rat) 81678

          View more View less

          Function(s)
          inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium ion transmembrane transporter activity phosphatidylinositol binding ion channel activity calcium channel activity calcium ion binding calcium-release channel activity inositol 1,4,5 trisphosphate binding
          Process(es)
          response to hypoxia transport ion transport calcium ion transport inositol phosphate-mediated signaling transmembrane transport calcium ion transmembrane transport cellular response to cAMP cellular response to ethanol cellular response to hypoxia signal transduction platelet activation regulation of insulin secretion release of sequestered calcium ion into cytosol regulation of cardiac conduction
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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