Proteintech

IPO11 Polyclonal Antibody

IPO11 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

IPO11 Antibody (14403-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 14403-1-AP (IPO11 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

IPO11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IPO11 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14403-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IPO11 Fusion Protein Ag5659 (1-350 aa encoded by BC033776)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDLNSASTV VLQVLTQATS QDTAVLKPAE EQLKQWETQP GFYSVLLNIF TNHTLDINVR WLAVLYFKHG IDRYWRRVAP HALSEEEKTT LRAGLITNFN EPINQIATQI AVLIAKVARL DCPRQWPELI PTLIESVKVQ DDLRQHRALL TFYHVTKTLA SKRLAADRKL FYDLASGIYN FACSLWNHHT DTFLQEVSSG NEAAILSSLE RTLLSLKVLR KLTVNGFVEP HKNMEVMGFL HGIFERLKQF LECSRSIGTD NVCRDRLEKT IILFTKVLLD FLDQHPFSFT PLIQRSLEFS VSYVFTEVGE GVTFERFIVQ CMNLIKMIVK NYAYKPSKNF EDSSPETLEA H (1-350 aa encoded by BC033776)

Target Information

IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.

Molecular cancer

Gu Y,Wang Y,He L,Zhang J,Zhu X,Liu N,Wang J,Lu T,He L,Tian Y,Fan Z

Thu Oct 14 00:00:00 UTC 2021

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.

Molecular cancer

Gu Y,Wang Y,He L,Zhang J,Zhu X,Liu N,Wang J,Lu T,He L,Tian Y,Fan Z

Thu Oct 14 00:00:00 UTC 2021

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.

Molecular cancer

Gu Y,Wang Y,He L,Zhang J,Zhu X,Liu N,Wang J,Lu T,He L,Tian Y,Fan Z

Thu Oct 14 00:00:00 UTC 2021

Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.

Molecular cancer

Gu Y,Wang Y,He L,Zhang J,Zhu X,Liu N,Wang J,Lu T,He L,Tian Y,Fan Z

Thu Oct 14 00:00:00 UTC 2021

Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses.

Genomics, proteomics & bioinformatics

Shi R,Feng Z,Zhang X

Fri Oct 01 00:00:00 UTC 2021

Importin-11 is Essential for Normal Embryonic Development in Mice.

International journal of medical sciences

Lee JY,Rahman FU,Kim EK,Cho SM,Kim HR,Lee K,Lee CS,Yoon WK,Moon OS,Seo YW,Won YS,Kim HC,Kim BH,Nam KH

Wed Dec 23 00:00:00 UTC 2020

Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.

Urologic oncology

Zhao J,Shi L,Zeng S,Ma C,Xu W,Zhang Z,Liu Q,Zhang P,Sun Y,Xu C

Fri Jun 01 00:00:00 UTC 2018

Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.

Urologic oncology

Zhao J,Shi L,Zeng S,Ma C,Xu W,Zhang Z,Liu Q,Zhang P,Sun Y,Xu C

Fri Jun 01 00:00:00 UTC 2018

Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.

Urologic oncology

Zhao J,Shi L,Zeng S,Ma C,Xu W,Zhang Z,Liu Q,Zhang P,Sun Y,Xu C

Fri Jun 01 00:00:00 UTC 2018

Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.

Urologic oncology

Zhao J,Shi L,Zeng S,Ma C,Xu W,Zhang Z,Liu Q,Zhang P,Sun Y,Xu C

Fri Jun 01 00:00:00 UTC 2018

Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival.

Oncotarget

Zhao J,Xu W,He M,Zhang Z,Zeng S,Ma C,Sun Y,Xu C

Tue Nov 15 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Imp11; Importin-11; Ran binding protein 11; Ran-binding protein 11; RanBP11

View more View less

Gene Aliases: 1700081H05Rik; 2510001A17Rik; AI314624; AW555235; E330021B14Rik; IPO11; RANBP11

View more View less

UniProt ID: (Human) Q9UI26, (Mouse) Q8K2V6

View more View less

Entrez Gene ID: (Human) 51194, (Rat) 310056, (Mouse) 76582

View more View less

Function(s)

protein binding Ran GTPase binding protein transporter activity

Process(es)

ribosomal protein import into nucleus transcription factor import into nucleus intracellular protein transport transport protein transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

IPO11 Polyclonal Antibody

IPO11 Antibody (14403-1-AP) in ICC/IF

Product Details

14403-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!