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Abnova
IPO8 Monoclonal Antibody (3D5)
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Product Details
H00010526-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3D5
Immunogen
IPO8 (NP_006381.2, 949 a.a. approximately 1037 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: LDLDNSVDEY QFFTQALITV QSRDAAWYQL LMAPLSEDQR TALQEVYTLA EHRRTVAEAK KKIEQQGGFT FENKGVLSAF NFGTVPSNN
Target Information
Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ26580; Imp8; Importin-8; RAN binding protein 8; Ran-binding protein 8; RanBP8
Gene Aliases: IPO8; RANBP8
UniProt ID: (Human) O15397
Entrez Gene ID: (Human) 10526
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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