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IQCG is a protein coding gene. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp434B227; Dynein regulatory complex protein 9; dynein regulatory complex subunit 9; IQ domain-containing protein G
Gene Aliases: 2400003L07Rik; CFAP122; DRC9; esgd12d; G1-374-12; IQCG; repro1; stubby12d
UniProt ID: (Human) Q9H095, (Mouse) Q80W32
Entrez Gene ID: (Human) 84223, (Mouse) 69707
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