Proteintech

IQGAP1 Polyclonal Antibody

IQGAP1 Antibody in Immunocytochemistry (ICC/IF)

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IQGAP1 Antibody (22167-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HeLa cells using 22167-1-AP (IQGAP1 antibody) at dilution of 1:400 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

IQGAP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IQGAP1 Antibody in Immunoprecipitation (IP)

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Product Details

22167-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:200-1:800

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IQGAP1 Fusion Protein Ag17821 (478-827 aa encoded by BC151834)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QLSSSVTGL TNIEEENCQR YLDELMKLKA QAHAENNEFI TWNDIQACVD HVNLVVQEEH ERILAIGLIN EALDEGDAQK TLQALQIPAA KLEGVLAEVA QHYQDTLIRA KREKAQEIQD ESAVLWLDEI QGGIWQSNKD TQEAQKFALG IFAINEAVES GDVGKTLSAL RSPDVGLYGV IPECGETYHS DLAEAKKKKL AVGDNNSKWV KHWVKGGYYY YHNLETQEGG WDEPPNFVQN SMQLSREEIQ SSISGVTAAY NREQLWLANE GLITRLQARC RGYLVRQEFR SRMNFLKKQI PAITCIQSQW RGYKQKKAYQ DRLAYLRSHK DEVVKIQSLA RMHQARKRYR D (478-827 aa encoded by BC151834)

Target Information

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration.

Cell death & disease

Hu Y,Xie Q,Wu X,Liu W,Li D,Li C,Zhao W,Chen L,Zheng Z,Li G,Guo J

Sat Oct 08 00:00:00 UTC 2022

Comprehensive analysis of the expression and prognosis for IQ motif-containing GTPase-activating proteins in hepatocellular carcinoma.

BMC cancer

Dai Q,Song F,Li X,Huang F,Zhao H

Tue Nov 01 00:00:00 UTC 2022

Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCδ for tumorigenesis.

Molecular cancer

Renaud E,Riegel K,Romero R,Suryamohan K,Distler U,Tenzer S,Schad A,Musholt TJ,Rajalingam K

Mon Oct 10 00:00:00 UTC 2022

The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells.

Oncogene

Birladeanu AM,Rogalska M,Potiri M,Papadaki V,Andreadou M,Kontoyiannis DL,Lewis JD,Erpapazoglou Z,Kafasla P

Wed Sep 01 00:00:00 UTC 2021

Anti-allergic drug azelastine suppresses colon tumorigenesis by directly targeting ARF1 to inhibit IQGAP1-ERK-Drp1-mediated mitochondrial fission.

Theranostics

Hu HF,Xu WW,Li YJ,He Y,Zhang WX,Liao L,Zhang QH,Han L,Yin XF,Zhao XX,Pan YL,Li B,He QY

Mon Aug 16 00:00:00 UTC 2021

MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation.

Biochemical and biophysical research communications

Zhang B,Xiao J,Cheng X,Liu T

Fri May 21 00:00:00 UTC 2021

Circadian locomotor output cycles kaput affects the proliferation and migration of breast cancer cells by regulating the expression of E-cadherin via IQ motif containing GTPase activating protein 1.

Oncology letters

Li X,Wang S,Yang S,Ying J,Yu H,Yang C,Liu Y,Wang Y,Cheng S,Xiao J,Guo H,Jiang Z,Wang Z

Tue May 01 00:00:00 UTC 2018

Circadian locomotor output cycles kaput affects the proliferation and migration of breast cancer cells by regulating the expression of E-cadherin via IQ motif containing GTPase activating protein 1.

Oncology letters

Li X,Wang S,Yang S,Ying J,Yu H,Yang C,Liu Y,Wang Y,Cheng S,Xiao J,Guo H,Jiang Z,Wang Z

Tue May 01 00:00:00 UTC 2018

IQGAP1 Mediates Hcp1-Promoted Escherichia coli Meningitis by Stimulating the MAPK Pathway.

Frontiers in cellular and infection microbiology

Zhao M,Zhang L,Lv S,Zhang C,Wang L,Chen H,Zhou Y,Lou J

Fri Dec 15 00:00:00 UTC 2017

IQGAP1 Mediates Hcp1-Promoted Escherichia coli Meningitis by Stimulating the MAPK Pathway.

Frontiers in cellular and infection microbiology

Zhao M,Zhang L,Lv S,Zhang C,Wang L,Chen H,Zhou Y,Lou J

Fri Dec 15 00:00:00 UTC 2017

IQGAP1 Mediates Hcp1-Promoted Escherichia coli Meningitis by Stimulating the MAPK Pathway.

Frontiers in cellular and infection microbiology

Zhao M,Zhang L,Lv S,Zhang C,Wang L,Chen H,Zhou Y,Lou J

Fri Dec 15 00:00:00 UTC 2017

IQGAP1 Mediates Hcp1-Promoted Escherichia coli Meningitis by Stimulating the MAPK Pathway.

Frontiers in cellular and infection microbiology

Zhao M,Zhang L,Lv S,Zhang C,Wang L,Chen H,Zhou Y,Lou J

Fri Dec 15 00:00:00 UTC 2017

Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1.

Oncotarget

Moon H,Ruelcke JE,Choi E,Sharpe LJ,Nassar ZD,Bielefeldt-Ohmann H,Parat MO,Shah A,Francois M,Inder KL,Brown AJ,Russell PJ,Parton RG,Hill MM

Fri Apr 10 00:00:00 UTC 2015

Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1.

Oncotarget

Moon H,Ruelcke JE,Choi E,Sharpe LJ,Nassar ZD,Bielefeldt-Ohmann H,Parat MO,Shah A,Francois M,Inder KL,Brown AJ,Russell PJ,Parton RG,Hill MM

Fri Apr 10 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Cdc42-Rac1 effector protein; DISP2; DISPB; p195; Ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs

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Gene Aliases: AA682088; D7Ertd237e; D7Ertd257e; HUMORFA01; IQGAP1; KIAA0051; mKIAA0051; p195; SAR1

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UniProt ID: (Human) P46940, (Mouse) Q9JKF1

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Entrez Gene ID: (Human) 8826, (Mouse) 29875

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Function(s)

GTPase inhibitor activity GTPase activator activity calcium ion binding protein binding calmodulin binding phosphatidylinositol-3,4,5-trisphosphate binding protein kinase binding protein phosphatase binding protein domain specific binding protein complex binding protein serine/threonine kinase activator activity S100 protein binding Rac GTPase binding cadherin binding involved in cell-cell adhesion Rho GTPase binding

Process(es)

regulation of cytokine production signal transduction epidermal growth factor receptor signaling pathway small GTPase mediated signal transduction fibroblast growth factor receptor signaling pathway negative regulation of dephosphorylation cellular response to platelet-derived growth factor stimulus regulation of GTPase activity cellular response to fibroblast growth factor stimulus positive regulation of protein kinase activity platelet-derived growth factor receptor signaling pathway cellular response to calcium ion cellular response to epidermal growth factor stimulus positive regulation of protein serine/threonine kinase activity neuron projection extension negative regulation of GTPase activity positive regulation of GTPase activity glomerular visceral epithelial cell development cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IQGAP1 Polyclonal Antibody

IQGAP1 Antibody (22167-1-AP) in ICC/IF

Product Details

22167-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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