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Proteintech
IQGAP3 Polyclonal Antibody
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Product Details
25930-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IQGAP3 Fusion Protein Ag23109 (530-880 aa encoded by BC131536)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LINEALDKG SPEKTLSALL LPAAGLDDVS LPVAPRYHLL LVAAKRQKAQ VTGDPGAVLW LEEIRQGVVR ANQDTNTAQR MALGVAAINQ AIKEGKAAQT ERVLRNPAVA LRGVVPDCAN GYQRALESAM AKKQCPADTA FWVQHDMKDG TAYYFHLQTF QGIWEQPPGC PLNTSHLTRE EIQSAVTKVT AAYDRQQLWK ANVGFVIQLQ ARLRGFLVRQ KFAEHSHFLR TWLPAVIKIQ AHWRGYRQRK IYLEWLQYFK ANLDAIIKIQ AWARMWAARR QYLRRLHYFQ KNVNSIVKIQ AFFRARKAQD DYRILVHAPH PPLSVVRRFA HLLNQSQQDF LAEAELLKLQ EE (530-880 aa encoded by BC131536)
Target Information
IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IQGA3; MGC10170; Ras GTPase-activating-like protein IQGAP3
Gene Aliases: IQGAP3
UniProt ID: (Human) Q86VI3
Entrez Gene ID: (Human) 128239
G1/S transition of mitotic cell cycle
activation of MAPK activity
Ras protein signal transduction
regulation of cell size
positive regulation of gene expression
negative regulation of gene expression
positive regulation of mammary gland epithelial cell proliferation
regulation of GTPase activity
ERK1 and ERK2 cascade
cellular response to organic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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