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Invitrogen
IQSEC1 Polyclonal Antibody
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Product Details
PA5-38019
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
19 amino acid peptide near the amino terminus of human IQSEC1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2554623
Product Specific Information
A recommended positive control is A-20 cell lysate.
At least four isoforms of IQSEC1 are known to exist. IQSEC1 antibody is not expected to cross-react with IQSEC2.
Target Information
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; BRAG2; brefeldin A-resistant ARF-GEF2; Brefeldin-resistant Arf-GEF 2 protein; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1
Gene Aliases: ARF-GEP100; ARFGEP100; AW561907; BC026481; BRAG2; cI-43; D6Ertd349e; GEP100; IQSEC1; KIAA0763
UniProt ID: (Human) Q6DN90, (Mouse) Q8R0S2
Entrez Gene ID: (Human) 9922, (Mouse) 232227, (Rat) 686590
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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