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Invitrogen
IREB2 Polyclonal Antibody
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IREB2 Antibody (PA1-16544) in IHC (P)
Immunohistochemical analysis of IREB2 in formalin fixed paraffin-embedded (FFPE) human placenta. Samples were incubated in IREB2 polyclonal antibody (Product # PA1-16544) using a dilution of 1:300. Bond Rx autostainer (Leica Biosystems). The assay involved 30 minutes of heat induced antigen retrieval (HIER) using 10 mM sodium citrate buffer (pH 9.0) and endogenous peroxidase quenching with peroxide block. T... View More
Product Details
PA1-16544
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an internal portion of the murine IRP2 protein sequence (between residues 100-200). UniProt Q811J3
Conjugate
Form
Liquid
Concentration
1.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2126582
Product Specific Information
This antibody has 94% sequence homology with human, primate and rat.
Suggested positive control: 3T3 whole cell lysate.
Target Information
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ23381; IRE-BP 2; Iron regulatory protein 2; iron-responsive element binding protein 2; Iron-responsive element-binding protein 2; IRP2
Gene Aliases: ACO3; D9Ertd85e; IREB2; IRP2; IRP2AD
UniProt ID: (Human) P48200, (Mouse) Q811J3
Entrez Gene ID: (Human) 3658, (Mouse) 64602
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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