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Invitrogen
IREB2 Monoclonal Antibody (9D1)
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FIGURE: 1 / 2
IREB2 Antibody (MA5-42529) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human placenta tissue using IREB2 Monoclonal Antibody (Product # MA5-42529). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the IREB2 antibody at a dilution of... View More
Product Details
MA5-42529
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
9D1
Immunogen
Recombinant protein within human IREB2 aa 1-963
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein G
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911670
Product Specific Information
Positive Control: Jurkat cell lysate, Daudi cell lysate, human liver tissue lysate, human placenta tissue.
Subcellular Location: Cytoplasm.
Target Information
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ23381; IRE-BP 2; Iron regulatory protein 2; iron-responsive element binding protein 2; Iron-responsive element-binding protein 2; IRP2
Gene Aliases: ACO3; IREB2; IRP2; IRP2AD
UniProt ID: (Human) P48200
Entrez Gene ID: (Human) 3658
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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