Bethyl Laboratories

IRF1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

A303-378A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 300 and 329 of mouse Interferon Regulatory Factor 1.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

tris citrate/phosphate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. Diseases associated with IRF1 include gastric cancer, somatic and lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Interferon regulatory factor 1; IRF-1

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Gene Aliases: AU020929; Irf-1; Irf1

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UniProt ID: (Mouse) P15314

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Entrez Gene ID: (Mouse) 16362

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Function(s)
regulatory region DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding
Process(es)
immune system process regulation of adaptive immune response transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter apoptotic process cell cycle arrest I-kappaB kinase/NF-kappaB signaling regulation of gene expression positive regulation of cell death positive regulation of type I interferon production positive regulation of interferon-beta production positive regulation of natural killer cell differentiation regulation of MyD88-dependent toll-like receptor signaling pathway cellular response to interferon-beta negative regulation of tyrosine phosphorylation of Stat1 protein CD8-positive, alpha-beta T cell differentiation positive regulation of interleukin-12 biosynthetic process innate immune response regulation of innate immune response negative regulation of regulatory T cell differentiation positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter defense response to virus interferon-gamma-mediated signaling pathway response to growth hormone cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to peptide hormone stimulus regulation of CD8-positive, alpha-beta T cell proliferation
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