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Proteintech
IRF4 Monoclonal Antibody (1A12D5)
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Product Details
66451-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A12D5
Immunogen
IRF4 Fusion Protein Ag25203 (1-451 aa encoded by BC015752)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNLEGGGRG GEFGMSAVSC GNGKLRQWLI DQIDSGKYPG LVWENEEKSI FRIPWKHAGK QDYNREEDAA LFKAWALFKG KFREGIDKPD PPTWKTRLRC ALNKSNDFEE LVERSQLDIS DPYKVYRIVP EGAKKGAKQL TLEDPQMSMS HPYTMTTPYP SLPAQQVHNY MMPPLDRSWR DYVPDQPHPE IPYQCPMTFG PRGHHWQGPA CENGCQVTGT FYACAPPESQ APGVPTEPSI RSAEALAFSD CRLHICLYYR EILVKELTTS SPEGCRISHG HTYDASNLDQ VLFPYPEDNG QRKNIEKLLS HLERGVVLWM APDGLYAKRL CQSRIYWDGP LALCNDRPNK LERDQTCKLF DTQQFLSELQ AFAHHGRSLP RFQVTLCFGE EFPDPQRQRK LITAHVEPLL ARQLYYFAQQ NSGHFLRGYD LPEHISNPED YHRSIRHSSI QE (1-451 aa encoded by BC015752)
Target Information
The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Interferon regulatory factor 4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; NF-EM5
Gene Aliases: IRF4; LSIRF; MUM1; NF-EM5; SHEP8
UniProt ID: (Human) Q15306
Entrez Gene ID: (Pig) 100144625, (Human) 3662, (Rat) 291100
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein-lysine N-methyltransferase activity
sequence-specific DNA binding
regulatory region DNA binding
molecular_function
regulation of transcription, DNA-templated
protein methylation
biological_process
peptidyl-lysine methylation
negative regulation of toll-like receptor signaling pathway
defense response to protozoan
myeloid dendritic cell differentiation
positive regulation of DNA binding
histone H3 acetylation
histone H4 acetylation
positive regulation of interleukin-10 biosynthetic process
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-13 biosynthetic process
positive regulation of interleukin-4 biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
T-helper 17 cell lineage commitment
transcription from RNA polymerase II promoter
T cell activation
regulation of T-helper cell differentiation
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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