Proteintech

IRF8 Polyclonal Antibody

IRF8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

IRF8 Antibody (18977-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma using 18977-1-AP (IRF8 antibody) at dilution of 1:100 (under 40x lens).

Product Image Gallery

Product Details

18977-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.11 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Resveratrol alleviates aluminum-induced intestinal barrier dysfunction in mice.

Environmental toxicology

Hao W,Zhu X,Liu Z,Song Y,Wu S,Lu X,Yang J,Jin C

Wed Jun 01 00:00:00 UTC 2022

Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Yang T,Ma X,Wang R,Liu H,Wei S,Jing M,Li H,Zhao Y

Wed Jun 01 00:00:00 UTC 2022

Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Yang T,Ma X,Wang R,Liu H,Wei S,Jing M,Li H,Zhao Y

Wed Jun 01 00:00:00 UTC 2022

Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Yang T,Ma X,Wang R,Liu H,Wei S,Jing M,Li H,Zhao Y

Wed Jun 01 00:00:00 UTC 2022

Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Yang T,Ma X,Wang R,Liu H,Wei S,Jing M,Li H,Zhao Y

Wed Jun 01 00:00:00 UTC 2022

Deacetylation of IRF8 inhibits iNOS expression and inflammation via SIRT1 in macrophages.

Immunobiology

Jia Y,Shen K,Yang Y,Cai W,Wang K,Zhang Y,Zhao M,Luo L,Su L,Guan H,Hu D

Tue Nov 01 00:00:00 UTC 2022

Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.

Life sciences

Yang T,Wang R,Liu H,Wang L,Li J,Wu S,Chen X,Yang X,Zhao Y

Mon Feb 01 00:00:00 UTC 2021

Cross-talk of pyroptosis and tumor immune landscape in lung adenocarcinoma.

Translational lung cancer research

Wang X,Lin W,Liu T,Xu Z,Wang Z,Cao Z,Feng X,Gao Y,He J

Wed Dec 01 00:00:00 UTC 2021

Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl₄/2-AAF.

Pharmaceutical biology

Xu Y,Xu W,Liu W,Chen G,Jiang S,Chen J,Jian X,Zhang H,Liu P,Mu Y

Wed Dec 01 00:00:00 UTC 2021

The unique regulation of implant surface nanostructure on macrophages M1 polarization.

Materials science & engineering. C, Materials for biological applications

He Y,Luo J,Zhang Y,Li Z,Chen F,Song W,Zhang Y

Wed Jan 01 00:00:00 UTC 2020

The unique regulation of implant surface nanostructure on macrophages M1 polarization.

Materials science & engineering. C, Materials for biological applications

He Y,Luo J,Zhang Y,Li Z,Chen F,Song W,Zhang Y

Wed Jan 01 00:00:00 UTC 2020

Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.

Journal of experimental & clinical cancer research : CR

Sheng W,Shi X,Lin Y,Tang J,Jia C,Cao R,Sun J,Wang G,Zhou L,Dong M

Fri Jan 17 00:00:00 UTC 2020

Mechanism of berberine in treating Helicobacter pylori induced chronic atrophic gastritis through IRF8-IFN-γ signaling axis suppressing.

Life sciences

Yang T,Wang R,Zhang J,Bao C,Zhang J,Li R,Chen X,Wu S,Wen J,Wei S,Li H,Cai H,Yang X,Zhao Y

Fri May 01 00:00:00 UTC 2020

Mechanism of berberine in treating Helicobacter pylori induced chronic atrophic gastritis through IRF8-IFN-γ signaling axis suppressing.

Life sciences

Yang T,Wang R,Zhang J,Bao C,Zhang J,Li R,Chen X,Wu S,Wen J,Wei S,Li H,Cai H,Yang X,Zhao Y

Fri May 01 00:00:00 UTC 2020

IRF8 is the target of SIRT1 for the inflammation response in macrophages.

Innate immunity

Jia Y,Han S,Li J,Wang H,Liu J,Li N,Yang X,Shi J,Han J,Li Y,Bai X,Su L,Hu D

Wed Feb 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: H-ICSBP; ICSBP; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; IRF-8; transcription factor ICSBP

View more View less

Gene Aliases: AI893568; H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B; IRF-8; IRF8; Myls

View more View less

UniProt ID: (Human) Q02556, (Mouse) P23611

View more View less

Entrez Gene ID: (Human) 3394, (Rat) 292060, (Mouse) 15900

View more View less

Function(s)

regulatory region DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding DNA binding transcription factor activity, sequence-specific DNA binding

Process(es)

phagocytosis immune response response to bacterium myeloid cell differentiation positive regulation of interferon-gamma production positive regulation of interleukin-12 production defense response to bacterium defense response to protozoan negative regulation of growth of symbiont in host positive regulation of transcription, DNA-templated positive regulation of transcription initiation from RNA polymerase II promoter cellular response to lipopolysaccharide negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated interferon-gamma-mediated signaling pathway type I interferon signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

IRF8 Polyclonal Antibody

IRF8 Antibody (18977-1-AP) in IHC (P)

Product Details

18977-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!