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Proteintech
IRG1 Polyclonal Antibody
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Product Details
28436-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: DAAASVRKHL VAERALLPTD YIKRIVLRIP NVQYVNRPFP VSEHEARHSF QYVACAMLLD GGITVPSFHE CQINRPQVRE LLSKVELEYP PDNLPSFNIL YCEISVTLKD GATFTDRSDT FYGHWRKPLS QEDLEEKFRA NASKMLSWDT VESLIKIVKN LEDLEDCSVL TTLLKGPSPP EVASNSPACN NSITNLS
Target Information
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aconitate decarboxylase; Aconitate decarboxylase 1; CAD; Cis-aconitate decarboxylase; Cis-aconitic acid decarboxylase; Immune-responsive gene 1 protein; immune-responsive gene 1 protein homolog; immunoresponsive 1 homolog
Gene Aliases: ACOD1; AI323667; CAD; IRG1
UniProt ID: (Human) A6NK06, (Mouse) P54987
Entrez Gene ID: (Human) 730249, (Mouse) 16365
positive regulation of antimicrobial humoral response
defense response
inflammatory response
embryo implantation
metabolic process
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
cellular response to interferon-beta
negative regulation of innate immune response
negative regulation of inflammatory response
cellular response to molecule of bacterial origin
cellular response to lipopolysaccharide
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to progesterone stimulus
tolerance induction to lipopolysaccharide
positive regulation of reactive oxygen species metabolic process
immune system process
propionate catabolic process
response to lipopolysaccharide
innate immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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