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Product Details
14090-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IRGC Fusion Protein Ag5279 (1-463 aa encoded by BC066939)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATSKLPVV PGEEENTILM AKERLEALRT AFESGDLPQA ASHLQELLAS TESIRLEVGV TGESGAGKSS LINALRGLEA EDPGAALTGV METTMQPSPY PHPQFPDVTL WDLPGAGSPG CPADKYLKQV DFSRYDFFLL VSPRRCGAVE TRLAAEILCQ GKKFYFVRTK VDEDLAATRT QRPSGFREAA VLQEIRDHCA ERLREAGVAD PRIFLVSNLS PARYDFPTLV STWEHDLPSH RRHAGLLSLP DISLEALQKK KAMLQEQVLK TALVLGVIQA LPVPGLAAAY DDALLIHSLR GYHRSFGLDD DSLAKLAEQV GKQAGDLRSV IRSPLANEVS PETVLRLYSQ SSDGAMRVAR AFERGIPVFG TLVAGGISFG AVYTMLQGCL NEMAEDAQRV RIKALEDDEP QPEVSLEVAS DNGVEKGGSG EGGGEEAPLS TCRKLGLLLK YILDSWKKHD SEEK (1-463 aa encoded by BC066939)
Target Information
Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cinema 1; Immunity-related GTPase cinema 1; immunity-related GTPase family, cinema 1; interferon inducible GTPase 5; interferon inducible GTPase family member 5; interferon-gamma-inducible GTPase IFGGE protein; Interferon-inducible GTPase 5
Gene Aliases: CINEMA; F630044M05Rik; Gm1102; Gm474; IFGGE; IIGP5; IRGC; IRGC1; R30953_1; RGD1311107
UniProt ID: (Human) Q6NXR0, (Rat) Q6AYF9
Entrez Gene ID: (Human) 56269, (Rat) 308428, (Mouse) 210145
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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