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IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.
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Protein Aliases: 160 kDa phosphotyrosine protein; Insulin receptor substrate 4; IRS-4; Phosphoprotein of 160 kDa; pp160; py160; RP23-415G1.3
Gene Aliases: IRS-4; IRS4; PY160
UniProt ID: (Human) O14654
Entrez Gene ID: (Human) 8471
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