Invitrogen

ISL1 Recombinant Rabbit Monoclonal Antibody (1G9Q8)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-35062

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1G9Q8

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Islet1 (P61371)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.51 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2848967

Product Specific Information

Immunogen sequence: YAANPRPDAL MKEQLVEMTG LSPRVIRVWF QNKRCKDKKR SIMMKQLQQQ QPNDKTNIQG MTGTPMVAAS PERHDGGLQA NPVEVQSYQP PWKVLSDFAL Q

Target Information

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Insulin gene enhancer protein ISL-1; insulin related protein; isl-1 homeobox; ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain; ISL1 transcription factor, LIM/homeodomain 1; Islet 1; Islet-1; Lim-homeodomain protein Islet1

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Gene Aliases: Isl-1; isl-1=homeobox; ISL1; ISLET1

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UniProt ID: (Human) P61371, (Mouse) P61372, (Rat) P61374

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Entrez Gene ID: (Human) 3670, (Mouse) 16392, (Rat) 64444

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity enhancer sequence-specific DNA binding chromatin binding protein binding zinc ion binding ligand-dependent nuclear receptor binding estrogen receptor binding bHLH transcription factor binding DNA binding sequence-specific DNA binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter neural crest cell migration heart morphogenesis secondary heart field specification outflow tract septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis regulation of secondary heart field cardioblast proliferation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development heart development positive regulation of cell proliferation regulation of gene expression positive regulation of vascular endothelial growth factor production spinal cord motor neuron cell fate specification spinal cord motor neuron differentiation visceral motor neuron differentiation trigeminal nerve development pituitary gland development neuron differentiation pancreas development retinal ganglion cell axon guidance positive regulation of insulin secretion positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production negative regulation of intracellular estrogen receptor signaling pathway positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of DNA binding negative regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter neuron fate commitment neuron fate specification mesenchymal cell differentiation sensory system development peripheral nervous system neuron development peripheral nervous system neuron axonogenesis negative regulation of inflammatory response ventricular cardiac muscle tissue morphogenesis pharyngeal system development cardiac muscle cell myoblast differentiation innervation atrial septum morphogenesis cardiac cell fate determination positive regulation of granulocyte colony-stimulating factor production negative regulation of protein homodimerization activity negative regulation of canonical Wnt signaling pathway positive regulation of macrophage colony-stimulating factor production regulation of transcription from RNA polymerase II promoter axon regeneration positive regulation of histone acetylation cellular response to glucocorticoid stimulus
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