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Invitrogen
ITGA4 Monoclonal Antibody (5C4)
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Product Details
MA5-17102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5C4
Immunogen
Purified recombinant fragment of human ITGA4 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538573
Product Specific Information
MA5-17102 targets ITGA4 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17102 immunogen is purified recombinant fragment of human ITGA4 expressed in E. Coli.
MA5-17102 detects ITGA4 which has a predicted molecular weight of approximately 115kDa.
Target Information
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; Integrin alpha-4; Integrin alpha-IV; ITGA-IV; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gene Aliases: CD49D; IA4; ITGA4
UniProt ID: (Human) P13612
Entrez Gene ID: (Human) 3676
cell-matrix adhesion involved in ameboidal cell migration
leukocyte cell-cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
B cell differentiation
extracellular matrix organization
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
endodermal cell differentiation
receptor clustering
regulation of immune response
leukocyte migration
leukocyte tethering or rolling
diapedesis
cellular response to cytokine stimulus
negative regulation of protein homodimerization activity
import into cell
positive regulation of leukocyte tethering or rolling
clathrin-mediated extracellular exosome endocytosis
positive regulation of T cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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