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Invitrogen
ITGA5 Polyclonal Antibody
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ITGA5 Antibody (PA5-78027) in WB
Western Blot using ITGA5 Polyclonal Antibody (Product # PA5-78027). Mouse tissue extract (50 µg) was separated by 5% SDS-PAGE, and the membrane was blotted with ITGA5 Polyclonal Antibody (Product # PA5-78027) diluted at 1:5,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-78027
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human Integrin alpha 5. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2735966
Product Specific Information
Positive Control: MDA-MB-231, MDA-MB-231 membrane fraction extract, mouse liver, rat liver
Predicted Reactivity: Bovine (85%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member E; CD49e; fibronectin receptor alpha polypeptide; Fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; integrin alpha 5; integrin alpha 5 (fibronectin receptor alpha); Integrin alpha-5; Integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); very late activation protein 5, alpha subunit; VLA-5
Gene Aliases: CD49e; FNRA; ITGA5; Itga5_retired; VLA-5; VLA5; VLA5A
UniProt ID: (Human) P08648, (Mouse) P11688
Entrez Gene ID: (Human) 3678, (Mouse) 16402, (Rat) 315346
cell-substrate junction assembly
cell adhesion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
integrin-mediated signaling pathway
memory
positive regulation of cell-substrate adhesion
positive regulation of cell migration
cell-substrate adhesion
cell-cell adhesion mediated by integrin
heterotypic cell-cell adhesion
endodermal cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of anoikis
angiogenesis
extracellular matrix organization
positive regulation of vascular endothelial growth factor receptor signaling pathway
wound healing, spreading of epidermal cells
viral entry into host cell
leukocyte migration
positive regulation of sprouting angiogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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