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Invitrogen
ITGB3BP Polyclonal Antibody
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Product Details
PA5-100723
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ITGB3BP(Accession Q13352), corresponding to amino acid residues T36-F86.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2850227
Product Specific Information
Antibody detects endogenous levels of total CENPR.
Target Information
ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta 3 endonexin; Beta-3-endonexin; beta3-endonexin; CENP-R; Centromere protein R; integrin beta 3 binding protein (beta3-endonexin); Integrin beta-3-binding protein; Nuclear receptor-interacting factor 3
Gene Aliases: 4930471O16Rik; AU022583; CENP-R; CENPR; HSU37139; ITGB3BP; NRIF3; TAP20
UniProt ID: (Human) Q13352, (Mouse) Q9CQ82
Entrez Gene ID: (Human) 23421, (Mouse) 67733
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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