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Invitrogen
ITGB5 Polyclonal Antibody
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ITGB5 Antibody (PA5-118499) in IHC (P)
Immunohistochemical analysis of ITGB5 in Human gastric cancer and adjacent normal tissues using a ITGB5 polyclonal antibody (Product # PA5-118499). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary a... View More
Product Details
PA5-118499
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ITGB5(Accession P18084), corresponding to amino acid residues A726-K776.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2903001
Product Specific Information
Antibody detects endogenous levels of total Integrin beta 5.
Target Information
Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD61; FLJ26658; GP3A; GPIIIa; integrin beta 5; Integrin beta-5; integrin, beta 5; testis secretory sperm-binding protein Li 217p
Gene Aliases: [b]-5; [b]5; [b]5A; [b]5B; AA475909; AI874634; beta-5; beta5; ESTM23; ITGB5; RGD1563276
UniProt ID: (Human) P18084, (Mouse) O70309
Entrez Gene ID: (Human) 3693, (Rat) 257645, (Mouse) 16419
cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
biological_process
endodermal cell differentiation
stress fiber assembly
epithelial cell-cell adhesion
cell adhesion
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
muscle contraction
extracellular matrix organization
viral entry into host cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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