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Invitrogen
ITIH1 (Cleaved Asp672) Polyclonal Antibody
FIGURE: 1 / 2
ITIH1 (Cleaved Asp672) Antibody (PA5-37430) in WB
Western blot analysis of ITIH1 (Cleaved Asp672) in Lane 1: A549 cell lysate, Lane 2: mouse lung tissue lysate, Lane 3: rat kidney tissue lysate. Samples were incubated with ITIH1 (Cleaved Asp672) polyclonal antibody (Product # PA5-37430) at a dilution of 1:500.
Product Details
PA5-37430
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 650-700 of human ITI-H1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2554056
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 71 and 101 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The inter-alpha trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I a IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. ITI-H1 contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, they are also associated with malignant transformation of lung tissue. ITI-H1 and ITI-H2 are associated with calcium oxalate stone formation in kidney and urine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: inter-alpha (globulin) inhibitor, H1 polypeptide; inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor complex component III; Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; Serum-derived hyaluronan-associated protein; SHAP
Gene Aliases: H1P; IATIH; IGHEP1; Intin1; ITI-HC1; ITIH; Itih-1; ITIH1; SHAP
UniProt ID: (Human) P19827, (Mouse) Q61702
Entrez Gene ID: (Human) 3697, (Mouse) 16424, (Rat) 306251
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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