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This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3.
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Protein Aliases: inter-alpha (globulin) inhibitor H3; inter-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-inhibitor heavy chain 3; Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; pre-alpha (globulin) inhibitor, H3 polypeptide; Serum-derived hyaluronan-associated protein; SHAP
Gene Aliases: H3P; ITI-HC3; ITIH3; SHAP
UniProt ID: (Human) Q06033
Entrez Gene ID: (Human) 3699
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