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FIGURE: 1 / 1
ITIH4 Antibody (PA5-88768) in WB
Western blot analysis of ITIH4 in extracts of various cell lines. Samples were incubated with ITIH4 Polyclonal antibody (Product # PA5-88768) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-88768
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 689-930 of human ITIH4 (NP_0022092)
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805117
Product Specific Information
Immunogen sequence: RLAILPASAP PATSNPDPAV SRVMNMKIEE TTMTTQTPAP IQAPSAILPL PGQSVERLCV DPRHRQGPVN LLSDPEQGVE VTGQYEREKA GFSWIEVTFK NPLVWVHASP EHVVVTRNRR SSAYKWKETL FSVMPGLKMT MDKTGLLLLS DPDKVTIGLL FWDGRGEGLR LLLRDTDRFS SHVGGTLGQF YQEVLWGSPA ASDDGRRTLR VQGNDHSATR ERRLDYQEGP PGVEISCWSV EL; Positive Samples: LO2, A-549
Target Information
The inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family is a classic example of protein-glycosaminoglycoprotein (PGP) complexes. They occur constitutively in plasma at relatively high concentrations and results from alternating combinations of three kinds of heavy chains with a common light chain called the bikunin proteoglycan. Bikunin has two proteinase inhibotor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686G21125; Gp120; IHRP; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); inter-alpha-inhibitor heavy chain 4; Inter-alpha-trypsin inhibitor family heavy chain-related protein; inter-alpha-trypsin inhibitor heavy chain family, member 4; Inter-alpha-trypsin inhibitor heavy chain H4; inter-alpha-trypsin inhibitor, heavy chain-like, 1; ITI heavy chain H4; Plasma kallikrein sensitive glycoprotein 120; plasma kallikrein-sensitive glycoprotein 120
Gene Aliases: GP120; H4P; IHRP; ITI-HC4; ITIH4; ITIHL1; PK-120; PK120; PRO1851
UniProt ID: (Human) Q14624
Entrez Gene ID: (Human) 3700
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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