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Product Details
MA5-15879
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5G6
Immunogen
Purified recombinant fragment of human ITK expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11154453
Product Specific Information
MA5-15879 targets ITK in indirect ELISA, flow cytometry, Western blot, and immunofluorescence applications and shows reactivity with Human samples.
The MA5-15879 immunogen is purified recombinant fragment of human ITK expressed in E. Coli. .
MA5-15879 detects ITK which has a predicted molecular weight of approximately 72kDa.
Target Information
ITK is a tyrosine kinase expressed in T-cells which contains both SH2 and SH3 domains. ITK is thought to play a role in T-cell proliferation and differentiation. The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Itk (also known as Emt or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini. Itk associates with CD28 and becomes activated subsequent to CD28 ligation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of mouse T-cell itk/tsk; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; Interleukin-2-inducible T-cell kinase; Kinase EMT; MGC126257; MGC126258; T-cell-specific kinase; Tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk
Gene Aliases: EMT; ITK; LPFS1; LYK; PSCTK2
UniProt ID: (Human) Q08881
Entrez Gene ID: (Human) 3702
cytokine production
NK T cell differentiation
adaptive immune response
cellular defense response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
activation of phospholipase C activity
interferon-gamma production
interleukin-4 production
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
T cell activation
regulation of cell proliferation
innate immune response
T cell receptor signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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