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Abnova
ITM2C Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
ITM2C Antibody (H00081618-B01P) in WB
Western Blot analysis of ITM2C expression in transfected 293T cell line (H00081618-T01) by ITM2C MaxPab polyclonal antibody.
Lane 1: ITM2C transfected lysate(25.41 KDa).
Lane 2: Non-transfected lysate.
Lane 1: ITM2C transfected lysate(25.41 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00081618-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ITM2C (AAH25742, 1 a.a. approximately 230 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK RGSSVGGVCY LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR RGTYLPQTYI IQEEMVVTEH VSDKEALGSF IYHLCNGKDT YRLRRRATRR RINKRGAKNC NAIRHFENTF VVETLICGVV
Target Information
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRICHOS domain containing 2C; Cerebral protein 14; hRPC.1050_D_4; Integral membrane protein 2C; integral membrane protein 3; Transmembrane protein BRI3
Gene Aliases: BRI3; BRICD2C; E25; E25C; hucep-14; ITM2C; ITM3; NPD018; PSEC0047
UniProt ID: (Human) Q9NQX7
Entrez Gene ID: (Human) 81618
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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