Proteintech

ITPKA Polyclonal Antibody

ITPKA Antibody in Immunocytochemistry (ICC/IF)

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ITPKA Antibody (14270-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using ITPKA antibody 14270-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

ITPKA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ITPKA Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14270-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,200

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ITPKA Fusion Protein Ag5588 (141-461 aa encoded by BC026331)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LLSDSESRS RGNVQLEAGE DVGQKNHWQK IRTMVNLPVI SPFKKRYAWV QLAGHTGSFK AAGTSGLILK RCSEPERYCL ARLMADALRG CVPAFHGVVE RDGESYLQLQ DLLDGFDGPC VLDCKMGVRT YLEEELTKAR ERPKLRKDMY KKMLAVDPEA PTEEEHAQRA VTKPRYMQWR EGISSSTTLG FRIEGIKKAD GSCSTDFKTT RSREQVLRVF EEFVQGDEEV LRRYLNRLQQ IRDTLEVSEF FRRHEVIGSS LLFVHDHCHR AGVWLIDFGK TTPLPDGQIL DHRRPWEEGN REDGYLLGLD NLIGILASLA ER (141-461 aa encoded by BC026331)

Target Information

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Frontiers in genetics

Du Q,Zhou R,Wang H,Li Q,Yan Q,Dang W,Guo J

Thu Feb 02 00:00:00 UTC 2023

A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca²⁺ Signaling Pathway.

Pharmaceuticals (Basel, Switzerland)

Liu J,Zhang C,Wang J,Huang Y,Shen D,Hu Y,Chu H,Yu X,Zhang L,Ma H

Mon Nov 28 00:00:00 UTC 2022

Sex-specific Regulation of Spine Density and Synaptic Proteins by G-protein-coupled Estrogen Receptor (GPER)1 in Developing Hippocampus.

Neuroscience

Li X,Johann S,Rune GM,Bender RA

Wed Sep 15 00:00:00 UTC 2021

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.

Neuron

Stoyas CA,Bushart DD,Switonski PM,Ward JM,Alaghatta A,Tang MB,Niu C,Wadhwa M,Huang H,Savchenko A,Gariani K,Xie F,Delaney JR,Gaasterland T,Auwerx J,Shakkottai VG,La Spada AR

Wed Feb 19 00:00:00 UTC 2020

Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum.

Journal of molecular cell biology

Peng J,Sheng AL,Xiao Q,Shen L,Ju XC,Zhang M,He ST,Wu C,Luo ZG

Mon Aug 19 00:00:00 UTC 2019

Clinical efficacy of recombinant human latrophilin 3 antibody in the treatment of pediatric asthma.

Experimental and therapeutic medicine

Liu M,Zhang J,Liu C

Mon Jan 01 00:00:00 UTC 2018

Clinical efficacy of recombinant human latrophilin 3 antibody in the treatment of pediatric asthma.

Experimental and therapeutic medicine

Liu M,Zhang J,Liu C

Mon Jan 01 00:00:00 UTC 2018

ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.

Diagnostic pathology

Li J,Zhu YH,Huang P,Zhang B,Sun J,Guan XY

Fri Aug 07 00:00:00 UTC 2015

ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.

Diagnostic pathology

Li J,Zhu YH,Huang P,Zhang B,Sun J,Guan XY

Fri Aug 07 00:00:00 UTC 2015

The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin.

Cytoskeleton (Hoboken, N.J.)

Ashour DJ,Pelka B,Jaaks P,Wundenberg T,Blechner C,Zobiak B,Failla AV,Windhorst S

Sun Feb 01 00:00:00 UTC 2015

The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin.

Cytoskeleton (Hoboken, N.J.)

Ashour DJ,Pelka B,Jaaks P,Wundenberg T,Blechner C,Zobiak B,Failla AV,Windhorst S

Sun Feb 01 00:00:00 UTC 2015

The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin.

Cytoskeleton (Hoboken, N.J.)

Ashour DJ,Pelka B,Jaaks P,Wundenberg T,Blechner C,Zobiak B,Failla AV,Windhorst S

Sun Feb 01 00:00:00 UTC 2015

The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin.

Cytoskeleton (Hoboken, N.J.)

Ashour DJ,Pelka B,Jaaks P,Wundenberg T,Blechner C,Zobiak B,Failla AV,Windhorst S

Sun Feb 01 00:00:00 UTC 2015

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.

International journal of cancer

Windhorst S,Kalinina T,Schmid K,Blechner C,Kriebitzsch N,Hinsch R,Chang L,Herich L,Schumacher U,Mayr GW

Thu Sep 15 00:00:00 UTC 2011

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.

International journal of cancer

Windhorst S,Kalinina T,Schmid K,Blechner C,Kriebitzsch N,Hinsch R,Chang L,Herich L,Schumacher U,Mayr GW

Thu Sep 15 00:00:00 UTC 2011

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.

International journal of cancer

Windhorst S,Kalinina T,Schmid K,Blechner C,Kriebitzsch N,Hinsch R,Chang L,Herich L,Schumacher U,Mayr GW

Thu Sep 15 00:00:00 UTC 2011

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.

International journal of cancer

Windhorst S,Kalinina T,Schmid K,Blechner C,Kriebitzsch N,Hinsch R,Chang L,Herich L,Schumacher U,Mayr GW

Thu Sep 15 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: EC 2.7.1.127; inositol 1,4,5-triphosphate 3-kinase; Inositol 1,4,5-trisphosphate 3-kinase A; inositol 145-triphosphate 3-kinase; Inositol-trisphosphate 3-kinase A; insP 3-kinase A; IP3 3 kinase A; IP3 3-kinase A; IP3-kinase A; IP3K A

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Gene Aliases: IP3-3KA; IP3KA; ITPKA

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UniProt ID: (Human) P23677, (Mouse) Q8R071, (Rat) P17105

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Entrez Gene ID: (Human) 3706, (Mouse) 228550, (Rat) 81677

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Function(s)

calmodulin-dependent protein kinase activity calmodulin binding ATP binding inositol-1,4,5-trisphosphate 3-kinase activity Rac GTPase binding nucleotide binding kinase activity transferase activity

Process(es)

inositol metabolic process protein phosphorylation signal transduction actin cytoskeleton organization inositol phosphate metabolic process regulation of synaptic plasticity positive regulation of dendritic spine morphogenesis dendritic spine maintenance phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ITPKA Polyclonal Antibody

ITPKA Antibody (14270-1-AP) in ICC/IF

Product Details

14270-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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