Proteintech

ITPKB Polyclonal Antibody

ITPKB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ITPKB Antibody (12816-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 12816-1-AP) (ITPKB antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

12816-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ITPKB Fusion Protein Ag3456 (1-350 aa encoded by BC015009)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

ITPKB can be cleaved into many fragments, this antibody can recognize the N-terminal peptide fragment.

Immunogen sequence: MAVYCYALN SLVIMNSANE MKSGGGPGPS GSETPPPPRR AVLSPGSVFS PGRGASFLFP PAESLSPEEP RSPGGWRSGR RRLNSSSGSG SGSSGSSVSS PSWAGRLRGD RQQVVAAGTL SPPGPEEAKR KLRILQRELQ NVQVNQKVGM FEAHIQAQSS AIQAPRSPRL GRAHSPSPCP FRSSSQPPGR VLVQGARSEE RRTKSWGEQC PETSGTDSGR KGGPSLCSSQ VKKGMPPLPG RAAPTGSEAQ GPSAFVRMEK GIPASPRCGS PTAMEIDKRG SPTPGTRSCL APSLGLFGAS LTMATEVAAR VTSTGPHRPQ DLALTEPSGR ARELEDLQPP EALVERQGQF L (1-350 aa encoded by BC015009)

Target Information

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates the level of calcium within the cell by releasing calcium from intracellular stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is is thought to regulate the influx of calcium across the plasma membrane. IP3K exists as three isoforms, IP3KA, B, and C. IP3KA, the most highly characterized isoform, is expressed in rat brain and testis. IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart. IP3K activity is stimulated in the presence of calmodulin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

ASN neuro

Ohene-Nyako M,Nass SR,Richard HT,Lukande R,Nicol MR,McRae M,Knapp PE,Hauser KF

Fri Mar 10 00:00:00 UTC 2023

Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status.

International journal of molecular sciences

Di Leva F,Filosi M,Oyston L,Silvestri E,Picard A,Lavdas AA,Lobbestael E,Baekelandt V,Neely GG,Pramstaller PP,Hicks AA,Corti C

Thu Jan 19 00:00:00 UTC 2023

Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status.

International journal of molecular sciences

Di Leva F,Filosi M,Oyston L,Silvestri E,Picard A,Lavdas AA,Lobbestael E,Baekelandt V,Neely GG,Pramstaller PP,Hicks AA,Corti C

Thu Jan 19 00:00:00 UTC 2023

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

Cell

Mo X,Niu Q,Ivanov AA,Tsang YH,Tang C,Shu C,Li Q,Qian K,Wahafu A,Doyle SP,Cicka D,Yang X,Fan D,Reyna MA,Cooper LAD,Moreno CS,Zhou W,Owonikoko TK,Lonial S,Khuri FR,Du Y,Ramalingam SS,Mills GB,Fu H

Thu May 26 00:00:00 UTC 2022

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca²⁺ mobilization and the inflammatory activity of dendritic cells.

Science signaling

Marongiu L,Mingozzi F,Cigni C,Marzi R,Di Gioia M,Garrè M,Parazzoli D,Sironi L,Collini M,Sakaguchi R,Morii T,Crosti M,Moro M,Schurmans S,Catelani T,Rotem R,Colombo M,Shears S,Prosperi D,Zanoni I,Granucci F

Tue Mar 30 00:00:00 UTC 2021

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca²⁺ mobilization and the inflammatory activity of dendritic cells.

Science signaling

Tue Mar 30 00:00:00 UTC 2021

Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency.

The Journal of allergy and clinical immunology

Almutairi A,Wallace JG,Jaber F,Alosaimi MF,Jones J,Sallam MTH,Elnagdy MH,Chou J,Sobh A,Geha RS

Mon Jun 01 00:00:00 UTC 2020

miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.

EMBO molecular medicine

Salta E,Sierksma A,Vanden Eynden E,De Strooper B

Thu Sep 01 00:00:00 UTC 2016

miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.

EMBO molecular medicine

Salta E,Sierksma A,Vanden Eynden E,De Strooper B

Thu Sep 01 00:00:00 UTC 2016

miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.

EMBO molecular medicine

Salta E,Sierksma A,Vanden Eynden E,De Strooper B

Thu Sep 01 00:00:00 UTC 2016

miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.

EMBO molecular medicine

Salta E,Sierksma A,Vanden Eynden E,De Strooper B

Thu Sep 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Inositol 1,4,5-trisphosphate 3-kinase B; Inositol-trisphosphate 3-kinase B; insP 3-kinase B; IP3 3-kinase B; IP3K B; IP3K-B; proliferation-inducing protein 37

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Gene Aliases: 1110033J02Rik; E130307H12Rik; IP3-3KB; IP3K; IP3K-B; IP3KB; ITPKB; PIG37

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UniProt ID: (Human) P27987, (Rat) P42335

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Entrez Gene ID: (Human) 3707, (Mouse) 320404, (Rat) 54260

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Function(s)

protein binding calmodulin binding ATP binding inositol-1,4,5-trisphosphate 3-kinase activity

Process(es)

MAPK cascade regulation of protein phosphorylation myeloid cell homeostasis signal transduction cell surface receptor signaling pathway inositol trisphosphate metabolic process negative regulation of neutrophil apoptotic process common myeloid progenitor cell proliferation inositol phosphate metabolic process positive thymic T cell selection negative regulation of myeloid cell differentiation positive regulation of Ras protein signal transduction positive regulation of alpha-beta T cell differentiation cellular response to calcium ion phosphorylation T cell differentiation thymic T cell selection

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ITPKB Polyclonal Antibody

ITPKB Antibody (12816-1-AP) in IHC (P)

Product Details

12816-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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