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Invitrogen
ITPR3 Polyclonal Antibody
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Product Details
PA5-88758
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1630-1870 of human ITPR3 (NP_0022152)
Conjugate
Form
Liquid
Concentration
2.83 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300, 0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805108
Product Specific Information
Immunogen sequence: EGSEAYQRCE SGGFLSKLIQ HTKDLMESEE KLCIKVLRTL QQMLLKKTKY GDRGNQLRKM LLQNYLQNRK STSRGDLPDP IGTGLDPDWS AIAATQCRLD KEGATKLVCD LITSTKNEKI FQESIGLAIH LLDGGNTEIQ KSFHNLMMSD KKSERFFKVL HDRMKRAQQE TKSTVAVNMN DLGSQPHEDR EPVDPTTKGR VASFSIPGSS SRYSLGPSLR RGHEVSERVQ SSEMGTSVLI M; Positive Samples: HeLa, LO2, HepG2; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
Target Information
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor, type 3; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; IP3R-3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
Gene Aliases: IP3R; IP3R3; Itpr-3; ITPR3
UniProt ID: (Human) Q14573, (Mouse) P70227
Entrez Gene ID: (Human) 3710, (Mouse) 16440
inositol hexakisphosphate binding
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium ion binding
protein binding
calcium-release channel activity
phosphatidylinositol binding
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
ion channel activity
calcium channel activity
transport
ion transport
calcium ion transport
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
memory
inositol phosphate-mediated signaling
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
protein homooligomerization
protein heterooligomerization
response to calcium ion
transmembrane transport
long-term synaptic potentiation
calcium ion transport into cytosol
calcium ion transmembrane transport
cellular response to cAMP
platelet activation
regulation of insulin secretion
release of sequestered calcium ion into cytosol
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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