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Product Details
PA5-100582
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IVNS1ABP(Accession Q9Y6Y0), corresponding to amino acid residues T403-R453.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850090
Product Specific Information
Antibody detects endogenous levels of total IVNS1ABP.
Target Information
IVNS1ABP is a protein coding gene involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aryl hydrocarbon receptor-associated 3; Aryl hydrocarbon receptor-associated protein 3; Influenza virus NS1A-binding protein; Influenza virus NS1A-binding protein homolog; kelch family protein Nd1; Kelch family protein Nd1-L; kelch-like family member 39; Kelch-like protein 39; NCX downstream gene 1; ND1-L2; Nd1-S; NS1-binding protein; NS1-binding protein homolog; NS1-BP
Gene Aliases: 1190004M08Rik; 1700126I16Rik; AA960440; ARA3; FLARA3; HSPC068; IVNS1ABP; KIAA0850; KLHL39; mKIAA0850; ND1; Nd1-L; Nd1-S; Nd1L; Nd1S; NS-1; NS1; NS1-BP; NS1BP
UniProt ID: (Human) Q9Y6Y0, (Mouse) Q920Q8
Entrez Gene ID: (Human) 10625, (Mouse) 117198, (Rat) 289089
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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