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Product Details
16667-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IYD Fusion Protein Ag10146 (33-289 aa encoded by BC056253)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EPRTRAEAR PWVDEDLKDS SDLHQAEEDA DEWQESEENV EHIPFSHNHY PEKEMVKRSQ EFYELLNKRR SVRFISNEQV PMEVIDNVIR TAGTAPSGAH TEPWTFVVVK DPDVKHKIRK IIEEEEEINY MKRMGHRWVT DLKKLRTNWI KEYLDTAPIL ILIFKQVHGF AANGKKKVHY YNEISVSIAC GILLAALQNA GLVTVTTTPL NCGPRLRVLL GRPAHEKLPM LLPVGYPSKE ATVPDLKRKP LDQIMVTV (33-289 aa encoded by BC056253 )
Target Information
This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dJ422F24.1; Iodotyrosine dehalogenase 1; Iodotyrosine deiodinase 1; IYD-1
Gene Aliases: C6orf71; DEHAL1; IYD; IYD-1; TDH4
UniProt ID: (Human) Q6PHW0
Entrez Gene ID: (Human) 389434
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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