Proteintech

Icam-1 Polyclonal Antibody

Icam-1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

Icam-1 Antibody (16174-1-AP) in ICC/IF

Immunofluorescent analysis of 4T1 cells using 16174-1-AP (Icam-1 antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IgG.

Icam-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Icam-1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16174-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.46 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specifically against mouse Icam-1.

Target Information

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The role of 14-3-3 in the progression of vascular inflammation induced by lipopolysaccharide.

International immunopharmacology

Tan H,Li J,Jia C,Huang H,Li L,Liao B,Long Y,Nie Y,Yu F

Thu Jun 01 00:00:00 UTC 2023

CTNNAL1 enhances glucocorticoid sensitivity in HDM-induced asthma mouse model through deactivating hsp90 signaling pathway.

Life sciences

Wu D,Liu L,Zhu J,Liu C,Long C,Liu C,Qu X,Liu H,Ji M,Qin X,Xiang Y

Sun Jan 15 00:00:00 UTC 2023

Hyperforin regulates renal fibrosis via targeting the PI3K-AKT/ICAM1 axis.

Cellular signalling

Yang S,Zhong S,Deng Z,Xie T,Yin G,Wang L,Liu J,Yang J,Long Z,Jiang X,Tan J

Tue Aug 01 00:00:00 UTC 2023

Hyperforin regulates renal fibrosis via targeting the PI3K-AKT/ICAM1 axis.

Cellular signalling

Yang S,Zhong S,Deng Z,Xie T,Yin G,Wang L,Liu J,Yang J,Long Z,Jiang X,Tan J

Tue Aug 01 00:00:00 UTC 2023

Hyperforin regulates renal fibrosis via targeting the PI3K-AKT/ICAM1 axis.

Cellular signalling

Yang S,Zhong S,Deng Z,Xie T,Yin G,Wang L,Liu J,Yang J,Long Z,Jiang X,Tan J

Tue Aug 01 00:00:00 UTC 2023

Hyperforin regulates renal fibrosis via targeting the PI3K-AKT/ICAM1 axis.

Cellular signalling

Yang S,Zhong S,Deng Z,Xie T,Yin G,Wang L,Liu J,Yang J,Long Z,Jiang X,Tan J

Tue Aug 01 00:00:00 UTC 2023

Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy.

Clinical science (London, England : 1979)

Gong W,Jiao Q,Yuan J,Luo H,Liu Y,Zhang Y,Chen Z,Xu X,Bai L,Zhang X

Fri Mar 31 00:00:00 UTC 2023

NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.

Life sciences

Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X

Thu Dec 15 00:00:00 UTC 2022

NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.

Life sciences

Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X

Thu Dec 15 00:00:00 UTC 2022

NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.

Life sciences

Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X

Thu Dec 15 00:00:00 UTC 2022

NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.

Life sciences

Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X

Thu Dec 15 00:00:00 UTC 2022

SARS-CoV-2 productively infects human brain microvascular endothelial cells.

Journal of neuroinflammation

Yang RC,Huang K,Zhang HP,Li L,Zhang YF,Tan C,Chen HC,Jin ML,Wang XR

Wed Jun 15 00:00:00 UTC 2022

SARS-CoV-2 productively infects human brain microvascular endothelial cells.

Journal of neuroinflammation

Yang RC,Huang K,Zhang HP,Li L,Zhang YF,Tan C,Chen HC,Jin ML,Wang XR

Wed Jun 15 00:00:00 UTC 2022

SARS-CoV-2 productively infects human brain microvascular endothelial cells.

Journal of neuroinflammation

Yang RC,Huang K,Zhang HP,Li L,Zhang YF,Tan C,Chen HC,Jin ML,Wang XR

Wed Jun 15 00:00:00 UTC 2022

SARS-CoV-2 productively infects human brain microvascular endothelial cells.

Journal of neuroinflammation

Yang RC,Huang K,Zhang HP,Li L,Zhang YF,Tan C,Chen HC,Jin ML,Wang XR

Wed Jun 15 00:00:00 UTC 2022

LncRNA LPAL2/miR-1287-5p/EGFR Axis Modulates TED-Derived Orbital Fibroblast Activation Through Cell Adhesion Factors.

The Journal of clinical endocrinology and metabolism

Wang N,Hou SY,Qi X,Deng M,Cao JM,Tong BD,Xiong W

Tue Jul 13 00:00:00 UTC 2021

ICAM-1 Targeted Drug Combination Nanoparticles Enhanced Gemcitabine-Paclitaxel Exposure and Breast Cancer Suppression in Mouse Models.

Pharmaceutics

Zhu L,Mu Q,Yu J,Griffin JI,Xu X,Ho RJY

Fri Dec 31 00:00:00 UTC 2021

Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus.

Frontiers in pharmacology

Wei J,Sun J,Zeng J,Ji E,Xu J,Tang C,Huo H,Zhang Y,Li H,Yang H

Tue Dec 07 00:00:00 UTC 2021

Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.

Bioscience reports

Liu Y,Zhang S,Li X,Liu E,Wang X,Zhou Q,Ye J,Wang JZ

Fri Feb 28 00:00:00 UTC 2020

Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain.

Acta pharmacologica Sinica

Zhou YQ,Liu DQ,Chen SP,Chen N,Sun J,Wang XM,Cao F,Tian YK,Ye DW

Sat Aug 01 00:00:00 UTC 2020

Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice.

Biochemical and biophysical research communications

Yang J,Zeng P,Liu L,Yu M,Su J,Yan Y,Ma J,Hu W,Yang X,Han J,Duan Y,Chen Y

Thu Apr 02 00:00:00 UTC 2020

The Selective RNA Polymerase I Inhibitor CX-5461 Mitigates Neointimal Remodeling in a Modified Model of Rat Aortic Transplantation.

Transplantation

Dai C,Sun M,Wang F,Zhu J,Wei Y,Guo X,Ma S,Dong B,Wang G,Jiang F,Wang J

Mon Oct 01 00:00:00 UTC 2018

Niaspan inhibits diabetic retinopathy‑induced vascular inflammation by downregulating the tumor necrosis factor‑α pathway.

Molecular medicine reports

Wang Y,Meng X,Yan H

Wed Mar 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: CD54; Human rhinovirus receptor; ICAM-1; Intercellular adhesion molecule 1; Ly 47; MALA-2; MALA2; MyD10; sCD54; soluble CD54; Surface antigen of activated B cells

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Gene Aliases: CD54; ICAM; Icam-1; Icam1; Ly-47; MALA-2

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UniProt ID: (Mouse) P13597, (Rat) Q00238

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Entrez Gene ID: (Mouse) 15894, (Rat) 25464

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Function(s)

integrin binding protein complex binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Icam-1 Polyclonal Antibody

Icam-1 Antibody (16174-1-AP) in ICC/IF

Product Details

16174-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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