Invitrogen

Ihh Polyclonal Antibody

View all (11) IHH antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-115399

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human IHH(Accession Q14623), corresponding to amino acid residues K108-R158.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900035

Product Specific Information

Antibody detects endogenous levels of total IHH.

Target Information

Ihh encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HHG-2; IHH; Indian hedgehog homolog; Indian hedgehog protein

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Gene Aliases: BDA1; HHG2; IHH

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UniProt ID: (Human) Q14623, (Mouse) P97812

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Entrez Gene ID: (Human) 3549, (Mouse) 16147, (Rat) 84399

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Function(s)
patched binding calcium ion binding peptidase activity protein binding hydrolase activity metal ion binding molecular_function
Process(es)
skeletal system development ossification patterning of blood vessels osteoblast differentiation in utero embryonic development cell fate specification morphogenesis of a branching structure vasculature development heart looping positive regulation of mesenchymal cell proliferation epithelial cell morphogenesis retinal pigment epithelium development proteoglycan metabolic process proteolysis cell communication smoothened signaling pathway cell-cell signaling multicellular organism development pattern specification process positive regulation of cell proliferation embryo development embryonic pattern specification negative regulation of signal transduction intein-mediated protein splicing cell differentiation vitelline membrane formation pancreas development positive regulation of chondrocyte differentiation positive regulation of collagen biosynthetic process negative regulation of T cell differentiation in thymus negative regulation of immature T cell proliferation in thymus positive regulation of T cell differentiation in thymus multicellular organism growth chondrocyte proliferation regulation of growth embryonic digit morphogenesis camera-type eye development negative regulation of apoptotic process bone resorption regulation of cell differentiation negative regulation of cell differentiation positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation negative regulation of eye pigmentation cell maturation embryonic digestive tract morphogenesis embryonic camera-type eye morphogenesis neuron development smooth muscle tissue development positive regulation of epithelial cell proliferation cartilage development camera-type eye photoreceptor cell fate commitment head morphogenesis somite development embryonic skeletal joint development epithelial cell-cell adhesion response to estradiol maternal process involved in female pregnancy
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