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Invitrogen
Importin 4 Polyclonal Antibody
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FIGURE: 1 / 8
Importin 4 Antibody (PA5-100069) in ICC/IF
Immunofluorescent analysis of Importin 4 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Importin 4 polyclonal antibody (Product # PA5-100069) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 4... View More
Product Details
PA5-100069
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IPO4(Accession Q8TEX9), corresponding to amino acid residues L440-N490.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2815599
Product Specific Information
Antibody detects endogenous levels of total IPO4.
Target Information
Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Imp4; Imp4a; Imp4b; importin 4a; Importin-4; Importin-4a; Importin-4b; Ran-binding protein 4; RanBP4
Gene Aliases: 8430408O15Rik; AA409693; Imp4; Imp4a; IMP4B; IPO4; RANBP4
UniProt ID: (Human) Q8TEX9, (Mouse) Q8VI75
Entrez Gene ID: (Human) 79711, (Rat) 290228, (Mouse) 75751
protein import into nucleus, docking
protein import into nucleus, translocation
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
NLS-bearing protein import into nucleus
ribosomal protein import into nucleus
protein transport
intracellular protein transport
transport
ribosome biogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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