Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Importin 4 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-90575
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 728-1081 of human IPO4 (NP_0789343)
Conjugate
Form
Liquid
Concentration
0.94 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806126
Product Specific Information
Immunogen sequence: LHKACQSCPS EPNTAALQAA LARVVPSYMQ AVNRERERQV VMAVLEALTG VLRSCGTLTL KPPGRLAELC GVLKAVLQRK TACQDTDEEE EEEDDDQAEY DAMLLEHAGE AIPALAAAAG GDSFAPFFAG FLPLLVCKTK QGCTVAEKSF AVGTLAETIQ GLGAASAQFV SRLLPVLLST AQEADPEVRS NAIFGMGVLA EHGGHPAQEH FPKLLGLLFP LLARERHDRV RDNICGALAR LLMASPTRKP EPQVLAALLH ALPLKEDLEE WVTIGRLFSF LYQSSPDQVI DVAPELLRIC SLILADNKIP PDTKAALLLL LTFLAKQHTD SFQAALGSLP VDKAQELQAV LGLS; Positive Samples: HeLa, SH-SY5Y, A-549, HepG2, Mouse brain, Mouse lung, Rat brain; Cellular Location: Cytoplasm, Nucleus
Target Information
Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Imp4; Imp4a; Imp4b; importin 4a; Importin-4; Importin-4a; Importin-4b; Ran-binding protein 4; RanBP4
Gene Aliases: 8430408O15Rik; AA409693; Imp4; Imp4a; IMP4B; IPO4; RANBP4
UniProt ID: (Human) Q8TEX9, (Mouse) Q8VI75
Entrez Gene ID: (Human) 79711, (Rat) 290228, (Mouse) 75751
protein import into nucleus, docking
protein import into nucleus, translocation
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
NLS-bearing protein import into nucleus
ribosomal protein import into nucleus
protein transport
intracellular protein transport
transport
ribosome biogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support