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Product Details
PA5-89979
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 878-1037 of human IPO8 (NP_0063812)
Conjugate
Form
Liquid
Concentration
1.01 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805874
Product Specific Information
Immunogen sequence: TRQLVNREDR SKAEKADMEE NEEISSDEEE TNVTAQAMQS NNGRGEDEEE EDDDWDEEVL EETALEGFST PLDLDNSVDE YQFFTQALIT VQSRDAAWYQ LLMAPLSEDQ RTALQEVYTL AEHRRTVAEA KKKIEQQGGF TFENKGVLSA FNFGTVPSNN; Positive Samples: HeLa, Jurkat, Mouse brain, Rat testis; Cellular Location: Cytoplasm, Nucleus
Target Information
Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette, sub-family C (CFTR/MRP), member 10; FLJ26580; Imp8; Importin-8; oocyte maturation 1; RAN binding protein 8; Ran-binding protein 8; RanBP8
Gene Aliases: 6230418K12Rik; Abcc10; C130009K11Rik; IPO8; MRP7; OM-1; Om1; RANBP8
UniProt ID: (Human) O15397, (Mouse) Q7TMY7
Entrez Gene ID: (Human) 10526, (Mouse) 320727
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