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Importin beta Polyclonal Antibody

Importin beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Importin beta Antibody (10077-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 10077-1-AP (Importin beta antibody) at dilution of 1:50 (under 10x lens).

Importin beta Antibody in Western Blot (WB)

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Product Details

10077-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Importin beta Fusion Protein Ag0122 (408-605 aa encoded by BC003572)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QAMPTLIEL MKDPSVVVRD TAAWTVGRIC ELLPEAAIND VYLAPLLQCL IEGLSAEPRV ASNVCWAFSS LAEAAYEAAD VADDQEEPAT YCLSSSFELI VQKLLETTDR PDGHQNNLRS SAYESLMEIV KNSAKDCYPA VQKTTLVIME RLQQVLQMES HIQSTSDRIQ FNDLQSLLCA TLQNVLRKVQ HQDALQISD (408-605 aa encoded by BC003572)

Target Information

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.

Autophagy

Yao H,Li J,Liu Z,Ouyang C,Qiu Y,Zheng X,Mu J,Xie Z

Mon May 01 00:00:00 UTC 2023

Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.

Autophagy

Yao H,Li J,Liu Z,Ouyang C,Qiu Y,Zheng X,Mu J,Xie Z

Mon May 01 00:00:00 UTC 2023

CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.

Molecular cancer

Pan Z,Xu T,Bao L,Hu X,Jin T,Chen J,Chen J,Qian Y,Lu X,Li L,Zheng G,Zhang Y,Zou X,Song F,Zheng C,Jiang L,Wang J,Tan Z,Huang P,Ge M

Mon Oct 03 00:00:00 UTC 2022

Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.

Viruses

Nakanishi A,Okumura H,Hashita T,Yamashita A,Nishimura Y,Watanabe C,Kamimura S,Hayashi S,Murakami S,Ito K,Iwao T,Ikeda A,Hirose T,Sunazuka T,Tanaka Y,Matsunaga T

Tue Nov 08 00:00:00 UTC 2022

Neddylation of PTEN regulates its nuclear import and promotes tumor development.

Cell research

Xie P,Peng Z,Chen Y,Li H,Du M,Tan Y,Zhang X,Lu Z,Cui CP,Liu CH,He F,Zhang L

Mon Mar 01 00:00:00 UTC 2021

Neddylation of PTEN regulates its nuclear import and promotes tumor development.

Cell research

Xie P,Peng Z,Chen Y,Li H,Du M,Tan Y,Zhang X,Lu Z,Cui CP,Liu CH,He F,Zhang L

Mon Mar 01 00:00:00 UTC 2021

African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.

Virologica Sinica

Zhuo Y,Guo Z,Ba T,Zhang C,He L,Zeng C,Dai H

Thu Apr 01 00:00:00 UTC 2021

Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells.

Cell death & disease

Zhu ZC,Liu JW,Yang C,Li MJ,Wu RJ,Xiong ZQ

Mon Feb 11 00:00:00 UTC 2019

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.

Oncogene

Zhu ZC,Liu JW,Li K,Zheng J,Xiong ZQ

Tue May 01 00:00:00 UTC 2018

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.

Oncogene

Zhu ZC,Liu JW,Li K,Zheng J,Xiong ZQ

Tue May 01 00:00:00 UTC 2018

Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.

PLoS pathogens

Luo W,Zhang J,Liang L,Wang G,Li Q,Zhu P,Zhou Y,Li J,Zhao Y,Sun N,Huang S,Zhou C,Chang Y,Cui P,Chen P,Jiang Y,Deng G,Bu Z,Li C,Jiang L,Chen H

Mon Jan 01 00:00:00 UTC 2018

Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.

PLoS pathogens

Luo W,Zhang J,Liang L,Wang G,Li Q,Zhu P,Zhou Y,Li J,Zhao Y,Sun N,Huang S,Zhou C,Chang Y,Cui P,Chen P,Jiang Y,Deng G,Bu Z,Li C,Jiang L,Chen H

Mon Jan 01 00:00:00 UTC 2018

Nuclear import of Nkx2-2 is mediated by multiple pathways.

Biochemical and biophysical research communications

Lin W,Xu P,Guo Y,Jia Q,Tao T

Sun Jan 22 00:00:00 UTC 2017

Nuclear import of Nkx2-2 is mediated by multiple pathways.

Biochemical and biophysical research communications

Lin W,Xu P,Guo Y,Jia Q,Tao T

Sun Jan 22 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: HGNC:6400; importin 1; importin 90; Importin beta; importin beta-1 subunit; Importin subunit beta-1; Importin-90; KapB1; karyopherin (importin) beta 1; karyopherin beta 1; Karyopherin subunit beta-1; karyopherin,beta 1; MGC2155; MGC2156; MGC2157; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97; SCG

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Gene Aliases: AA409963; IMB1; Impnb; IPO1; IPOB; KPNB1; NTF97

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UniProt ID: (Human) Q14974, (Rat) P52296, (Mouse) P70168

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Entrez Gene ID: (Human) 3837, (Rat) 24917, (Mouse) 16211

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Function(s)

protein binding nuclear localization sequence binding zinc ion binding Ran GTPase binding protein transporter activity enzyme binding protein domain specific binding poly(A) RNA binding Hsp90 protein binding kinesin binding protein complex binding

Process(es)

protein import into nucleus ribosomal protein import into nucleus intracellular protein transport nucleocytoplasmic transport transport protein transport protein import into nucleus, docking protein import into nucleus, translocation apoptotic DNA fragmentation NLS-bearing protein import into nucleus mitotic chromosome movement towards spindle pole mitotic metaphase plate congression modulation by virus of host process astral microtubule organization Ran protein signal transduction establishment of mitotic spindle localization establishment of protein localization intracellular transport of virus mitotic spindle assembly

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Importin beta Polyclonal Antibody

Importin beta Antibody (10077-1-AP) in IHC (P)

Product Details

10077-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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