Bioss

Integrin Alpha V + Beta 5 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-1356R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Integrin beta 5 and Integrin alpha V.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha v integrin; antigen identified by monoclonal antibody L230; CD51; Dnmt3l-ps1 pseudogene; integrin alpha V; Integrin alpha-V; integrin alphaVbeta3; integrin beta 5; Integrin beta-5; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 5; testis secretory sperm-binding protein Li 217p; Vitronectin receptor; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha

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Gene Aliases: 1110004F14Rik; 2610028E01Rik; [b]-5; [b]5; [b]5A; [b]5B; AA475909; AI874634; beta-5; beta5; CD51; D430040G12Rik; ESTM23; ITGAV; ITGB5; MSK8; RGD1563276; VNRA; VTNR

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UniProt ID: (Human) P06756, (Human) P18084, (Mouse) P43406, (Mouse) O70309

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Entrez Gene ID: (Human) 3685, (Human) 3693, (Rat) 296456, (Mouse) 16410, (Rat) 257645, (Mouse) 16419

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Function(s)
virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding voltage-gated calcium channel activity protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding metal ion binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding receptor binding peptide binding protein heterodimerization activity integrin binding receptor activity
Process(es)
angiogenesis blood vessel development vasculogenesis cellular calcium ion homeostasis cell adhesion cell-matrix adhesion positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage cell growth cell migration positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway apoptotic cell clearance positive regulation of MAPK cascade negative regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of cell adhesion viral entry into host cell negative regulation of lipoprotein metabolic process regulation of phagocytosis negative chemotaxis ERK1 and ERK2 cascade calcium ion transmembrane transport extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic cell clearance negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway inflammatory response multicellular organism development fertilization cell differentiation detection of molecule of bacterial origin regulation of ion transmembrane transport gonad morphogenesis T cell activation endothelial cell migration regulation of bone resorption focal adhesion assembly release of sequestered calcium ion into cytosol trophoblast giant cell differentiation response to nitric oxide transforming growth factor beta receptor signaling pathway biological_process stress fiber assembly epithelial cell-cell adhesion antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent extracellular matrix organization vascular endothelial growth factor receptor signaling pathway leukocyte migration entry of symbiont into host cell by promotion of host phagocytosis muscle contraction
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