Proteintech

Integrin alpha-3 Monoclonal Antibody (3F9G4)

Integrin alpha-3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 10

Integrin alpha-3 Antibody (66070-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 66070-1-IG (Integrin alpha-3 antibody) at dilution of 1:4000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Integrin alpha-3 Antibody in Western Blot (WB)

Integrin alpha-3 Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

66070-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000-1:8,000

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig

Published species

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

3F9G4

Immunogen

Integrin alpha-3 Fusion Protein Ag17293 (52-376 aa encoded by BC150190)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.89 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize the heavy chain.

Immunogen sequence: FGYSVALHR QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL LHGPSGSAFG LSVASI (52-376 aa encoded by BC150190)

Target Information

ITGA3 (INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. ITGA3 is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the alpha3beta1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit. A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the western blot analysis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity.

Proceedings of the National Academy of Sciences of the United States of America

Mayner JM,Masutani EM,Demeester E,Kumar A,Macapugay G,Beri P,Lo Sardo V,Engler AJ

Tue Jun 13 00:00:00 UTC 2023

Hyaluronic acid-g-lipoic acid granular gel for promoting diabetic wound healing.

Bioengineering & translational medicine

Zhang S,Pan Y,Mao Z,Zhang J,Zhang K,Yin J,Wang C

Wed Mar 01 00:00:00 UTC 2023

Swine acute diarrhea syndrome coronavirus induces autophagy to promote its replication via the Akt/mTOR pathway.

iScience

Zeng S,Zhao Y,Peng O,Xia Y,Xu Q,Li H,Xue C,Cao Y,Zhang H

Fri Nov 18 00:00:00 UTC 2022

An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family.

PloS one

Cegarra C,Cameron B,Chaves C,Dabdoubi T,Do TM,Genêt B,Roudières V,Shi Y,Tchepikoff P,Lesuisse D

Mon Sep 19 00:00:00 UTC 2022

Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways.

Frontiers in molecular biosciences

Huang A,Wang R,Cui J,Gao Y,Yin Z,Chen L,He M,Li W

Tue Apr 05 00:00:00 UTC 2022

Angiopoietin 2 stimulates trophoblast invasion via a mechanism associated with JNK signaling.

Molecular human reproduction

Hou H,Ning F,Zhang JY,Lu Q,Zhang M,Wu P,Chen M,Lash GE

Sat Feb 27 00:00:00 UTC 2021

Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy.

Journal of materials chemistry. B

Tang Z,Lu Y,Zhang S,Wang J,Wang Q,Xiao Y,Zhang X

Wed Dec 15 00:00:00 UTC 2021

Clinical and Molecular Characterizations of Papillary Thyroid Cancer in Children and Young Adults: A Multicenter Retrospective Study.

Thyroid : official journal of the American Thyroid Association

Guo K,Qian K,Shi Y,Sun T,Chen L,Mei D,Dong K,Gu S,Liu J,Lv Z,Wang Z

Mon Nov 01 00:00:00 UTC 2021

Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.

Cell adhesion & migration

Jin Y,Liu W,Wang F,Wang M,Xu K,Yang A,Wang C,Zhang L,Zhang F,Li M

Wed Dec 01 00:00:00 UTC 2021

FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins.

International journal of oncology

Xu J,Lu W

Sat Aug 01 00:00:00 UTC 2020

FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins.

International journal of oncology

Xu J,Lu W

Sat Aug 01 00:00:00 UTC 2020

FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins.

International journal of oncology

Xu J,Lu W

Sat Aug 01 00:00:00 UTC 2020

Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis.

Cell death & disease

Jiang K,Dong C,Yin Z,Li R,Mao J,Wang C,Zhang J,Gao Z,Liang R,Wang Q,Wang L

Thu Nov 12 00:00:00 UTC 2020

Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431.

Molecular & cellular proteomics : MCP

Ren Y,Hao P,Law SK,Sze SK

Sat Nov 01 00:00:00 UTC 2014

Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431.

Molecular & cellular proteomics : MCP

Ren Y,Hao P,Law SK,Sze SK

Sat Nov 01 00:00:00 UTC 2014

Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431.

Molecular & cellular proteomics : MCP

Ren Y,Hao P,Law SK,Sze SK

Sat Nov 01 00:00:00 UTC 2014

Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431.

Molecular & cellular proteomics : MCP

Ren Y,Hao P,Law SK,Sze SK

Sat Nov 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: alpha 3 subunit of VLA-3 receptor; Alpha3 integrin; antigen CD49C; antigen identified by monoclonal antibody J143; CD49 antigen-like family member C; CD49c; CD49c antigen; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAPB3; integrin alpha 3; Integrin alpha-3; Integrin alpha3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); testicular tissue protein Li 96; testicular tissue protein Li 98; very late activation protein 3 receptor, alpha-3 subunit; VLA-3 subunit alpha

View more View less

Gene Aliases: AA407068; CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; ITGA3; MSK18; VCA-2; VL3A; VLA3a

View more View less

UniProt ID: (Human) P26006, (Mouse) Q62470

View more View less

Entrez Gene ID: (Human) 3675, (Mouse) 16400

View more View less

Function(s)

glycoprotein binding fibronectin binding protease binding integrin binding protein binding collagen binding protein domain specific binding laminin binding metal ion binding protein heterodimerization activity

Process(es)

neuron migration cell-matrix adhesion integrin-mediated signaling pathway heart development memory positive regulation of gene expression positive regulation of epithelial cell migration positive regulation of cell-substrate adhesion positive regulation of neuron projection development regulation of transforming growth factor beta receptor signaling pathway regulation of Wnt signaling pathway extracellular matrix organization lung development regulation of BMP signaling pathway negative regulation of cell projection organization response to gonadotropin negative regulation of Rho protein signal transduction exploration behavior response to drug skin development mesodermal cell differentiation leukocyte migration maternal process involved in female pregnancy nephron development positive regulation of establishment of protein localization to plasma membrane dendritic spine maintenance renal filtration

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Integrin alpha-3 Monoclonal Antibody (3F9G4)

Integrin alpha-3 Antibody (66070-1-IG) in IHC (P)

Product Details

66070-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!