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MUbio
Integrin alpha 3B Monoclonal Antibody (54B3)
Product Details
MUB0902P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
54B3
Immunogen
Integrin alpha 3B
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
54B3 recognizes specifically the cytoplasmic domain of integrin subunit alpha-3B which is present in microvascular structures in brain and heart.
A broad species reactivity is expected because of the conserved nature of the epitope.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Target Information
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha-3 and alpha-6, two cytoplasmic variants, A and B, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 3 subunit of VLA-3 receptor; antigen CD49C; antigen identified by monoclonal antibody J143; CD49 antigen-like family member C; CD49c; FRP-2; Galactoprotein B3; GAPB3; integrin alpha 3; Integrin alpha-3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); testicular tissue protein Li 96; testicular tissue protein Li 98; very late activation protein 3 receptor, alpha-3 subunit; VLA-3 subunit alpha
Gene Aliases: CD49C; FRP-2; GAP-B3; GAPB3; ILNEB; ITGA3; MSK18; VCA-2; VL3A; VLA3a
UniProt ID: (Human) P26006
Entrez Gene ID: (Human) 3675
neuron migration
cell-matrix adhesion
integrin-mediated signaling pathway
heart development
memory
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
regulation of transforming growth factor beta receptor signaling pathway
regulation of Wnt signaling pathway
extracellular matrix organization
lung development
regulation of BMP signaling pathway
negative regulation of cell projection organization
response to gonadotropin
negative regulation of Rho protein signal transduction
exploration behavior
response to drug
skin development
mesodermal cell differentiation
leukocyte migration
maternal process involved in female pregnancy
nephron development
positive regulation of establishment of protein localization to plasma membrane
dendritic spine maintenance
renal filtration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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