Proteintech

Integrin alpha-4 Polyclonal Antibody

Integrin alpha-4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

Integrin alpha-4 Antibody (19676-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 19676-1-AP ( Integrin alpha-4 Antibody) at dilution of 1:50.

Integrin alpha-4 Antibody in Western Blot (WB)

Integrin alpha-4 Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

19676-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-dependent

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Roles of cuproptosis-related gene DLAT in various cancers: a bioinformatic analysis and preliminary verification on pro-survival autophagy.

PeerJ

Yang Q,Zeng S,Liu W

Sat Apr 01 00:00:00 UTC 2023

Biomimetic liposomal nanozymes improve breast cancer chemotherapy with enhanced penetration and alleviated hypoxia.

Journal of nanobiotechnology

Li J,Gong C,Chen X,Guo H,Tai Z,Ding N,Gao S,Gao Y

Mon Apr 10 00:00:00 UTC 2023

Chidamide suppresses adipogenic differentiation of bone marrow derived mesenchymal stem cells via increasing REEP2 expression.

iScience

Zhang X,Liu L,Liu X,Huang Q,Liu L,Liu H,Ren S,Wei P,Cheng P,Yao M,Song W,Zhang H,Chen M

Fri Mar 17 00:00:00 UTC 2023

Increased expression of cell adhesion molecules in myofasciitis.

Frontiers in neurology

Ma X,Gao H,Xu L,Bi Z,Ji S,Bu B

Sun May 28 00:00:00 UTC 2023

Cimigenol depresses acute myeloid leukemia cells protected by breaking bone marrow stromal cells via CXCR4/SDF‑1α.

Experimental and therapeutic medicine

Ma B,Dai H,Dai X,Qian S,Sha X,Sun X

Wed Feb 01 00:00:00 UTC 2023

High Targeting Specificity toward Pulmonary Inflammation Using Mesenchymal Stem Cell-Hybrid Nanovehicle for an Efficient Inflammation Intervention.

Advanced healthcare materials

Su Y,Huang T,Sun H,Lin R,Zheng X,Bian Q,Zhang J,Chen S,Wu H,Xu D,Zhang T,Gao J

Fri Sep 01 00:00:00 UTC 2023

EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model.

The Journal of experimental medicine

Tao X,Zhang R,Du R,Yu T,Yang H,Li J,Wang Y,Liu Q,Zuo S,Wang X,Lazarus M,Zhou L,Wang B,Yu Y,Shen Y

Mon May 02 00:00:00 UTC 2022

Cell membrane-coated human hair nanoparticles for precise disease therapies.

Journal of nanobiotechnology

Zhang Y,Li Y,Xia Q,Li Y,Jin S,Mao Q,Liu C,Fan X,Lin H

Wed Nov 16 00:00:00 UTC 2022

Midkine mediates dysfunction of liver sinusoidal endothelial cells through integrin α4 and α6.

Vascular pharmacology

Wu L,Chen H,Fu C,Xing M,Fang H,Yang F,Yang Q,Zhang Y,Li W,Chen Z

Thu Dec 01 00:00:00 UTC 2022

Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.

Journal of neuroinflammation

Gao C,Jia W,Xu W,Wu Q,Wu J

Sat May 22 00:00:00 UTC 2021

Induced Pluripotent Stem Cell-Derived Conditioned Medium Promotes Endogenous Leukemia Inhibitory Factor to Attenuate Endotoxin-Induced Acute Lung Injury.

International journal of molecular sciences

Su VY,Chiou SH,Chen WC,Yu WK,Wu HH,Chen H,Yang KY

Mon May 24 00:00:00 UTC 2021

Fe₃O₄@M nanoparticles for MRI-targeted detection in the early lesions of atherosclerosis.

Nanomedicine : nanotechnology, biology, and medicine

Huang X,Lin C,Luo C,Guo Y,Li J,Wang Y,Xu J,Zhang Y,Wang H,Liu Z,Chen B

Thu Apr 01 00:00:00 UTC 2021

Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAF^V600E Mutant Melanoma Lung Metastasis in Mice.

International journal of molecular sciences

Cvetanova B,Li MY,Yang CC,Hsiao PW,Yang YC,Feng JH,Shen YC,Nakagawa-Goto K,Lee KH,Shyur LF

Mon Mar 22 00:00:00 UTC 2021

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy.

Journal of nanobiotechnology

Gong C,Yu X,You B,Wu Y,Wang R,Han L,Wang Y,Gao S,Yuan Y

Tue Jun 16 00:00:00 UTC 2020

Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease.

Nature communications

Ohkuro M,Kim JD,Kuboi Y,Hayashi Y,Mizukami H,Kobayashi-Kuramochi H,Muramoto K,Shirato M,Michikawa-Tanaka F,Moriya J,Kozaki T,Takase K,Chiba K,Agarwala KL,Kimura T,Kotake M,Kawahara T,Yoneda N,Hirota S,Azuma H,Ozasa-Komura N,Ohashi Y,Muratani M,Kimura K,Hishinuma I,Fukamizu A

Thu May 17 00:00:00 UTC 2018

Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease.

Nature communications

Thu May 17 00:00:00 UTC 2018

Membrane microvesicles as mediators for melanoma-fibroblasts communication: roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.

Cancer letters

Zhao XP,Wang M,Song Y,Song K,Yan TL,Wang L,Liu K,Shang ZJ

Fri May 01 00:00:00 UTC 2015

Membrane microvesicles as mediators for melanoma-fibroblasts communication: roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.

Cancer letters

Zhao XP,Wang M,Song Y,Song K,Yan TL,Wang L,Liu K,Shang ZJ

Fri May 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; Integrin alpha-4; Integrin alpha-IV; ITGA-IV; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha

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Gene Aliases: CD49D; IA4; ITGA4

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UniProt ID: (Human) P13612

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Entrez Gene ID: (Human) 3676

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Function(s)

fibronectin binding protein binding coreceptor activity C-X3-C chemokine binding metal ion binding cell adhesion molecule binding protein antigen binding

Process(es)

cell-matrix adhesion involved in ameboidal cell migration leukocyte cell-cell adhesion cell-matrix adhesion integrin-mediated signaling pathway B cell differentiation extracellular matrix organization heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading endodermal cell differentiation receptor clustering regulation of immune response leukocyte migration leukocyte tethering or rolling diapedesis cellular response to cytokine stimulus negative regulation of protein homodimerization activity import into cell positive regulation of leukocyte tethering or rolling clathrin-mediated extracellular exosome endocytosis positive regulation of T cell migration

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Integrin alpha-4 Polyclonal Antibody

Integrin alpha-4 Antibody (19676-1-AP) in IHC (P)

Product Details

19676-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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