NeoBiotechnologies

Integrin alpha V + beta 6 Monoclonal Antibody (AvB6 53a.2)

View all (4) ITGAV/ITGB6 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

RTM1-2500-P0

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

0.5-1 µg/10^6 cells
-

ELISA (ELISA)

1-5 µg/mL
-

Immunoprecipitation (IP)

1-2 µg/500 µg protein
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

AvB6 53a.2

Immunogen

Mouse fibroblasts retrovirally infected with cDNA to human beta6. Cells expressed a mouse/human avb6 chimera.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha v integrin; antigen identified by monoclonal antibody L230; CD51; integrin alpha V; Integrin alpha-V; integrin alphaVbeta3; integrin beta 6; Integrin beta-6; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 6; Vitronectin receptor; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha

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Gene Aliases: 1110004F14Rik; 2210409C20Rik; 2610028E01Rik; 4831415H04Rik; AI1H; CD51; D430040G12Rik; ITGAV; ITGB6; MSK8; VNRA; VTNR

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UniProt ID: (Human) P06756, (Human) P18564, (Mouse) P43406, (Mouse) Q9Z0T9

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Entrez Gene ID: (Human) 3685, (Human) 3694, (Mouse) 16410, (Mouse) 16420

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Function(s)
virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding voltage-gated calcium channel activity protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding metal ion binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding integrin binding receptor binding peptide binding protein heterodimerization activity receptor activity
Process(es)
angiogenesis blood vessel development cellular calcium ion homeostasis inflammatory response cell adhesion cell-matrix adhesion positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway multicellular organism development positive regulation of cell proliferation fertilization negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage cell growth cell migration cell differentiation positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport detection of molecule of bacterial origin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading regulation of ion transmembrane transport gonad morphogenesis endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway T cell activation apoptotic cell clearance positive regulation of MAPK cascade endothelial cell migration regulation of bone resorption negative regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of cell adhesion viral entry into host cell focal adhesion assembly negative regulation of lipoprotein metabolic process regulation of phagocytosis negative chemotaxis release of sequestered calcium ion into cytosol trophoblast giant cell differentiation ERK1 and ERK2 cascade calcium ion transmembrane transport response to nitric oxide extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic cell clearance negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent extracellular matrix organization vascular endothelial growth factor receptor signaling pathway leukocyte migration entry of symbiont into host cell by promotion of host phagocytosis
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