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Proteintech
Integrin beta-7 Polyclonal Antibody
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Integrin beta-7 Antibody (11328-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using (Product # 11328-1-AP) (Integrin Beta 7 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
11328-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Integrin beta-7 Fusion Protein Ag1871 (499-798 aa encoded by BC015916)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VCSCAPGRL GRLCECSVAE LSSPDLESGC RAPNGTGPLC SGKGHCQCGR CSCSGQSSGH LCECDDASCE RHEGILCGGF GRCQCGVCHC HANRTGRACE CSGDMDSCIS PEGGLCSGHG RCKCNRCQCL DGYYGALCDQ CPGCKTPCER HRDCAECGAF RTGPLATNCS TACAHTNVTL ALAPILDDGW CKERTLDNQL FFFLVEDDAR GTVVLRVRPQ EKGADHTQAI VLGCVGGIVA VGLGLVLAYR LSVEIYDRRE YSRFEKEQQQ LNWKQDSNPL YKSAITTTIN PRFQEADSPT L (499-798 aa encoded by BC015916)
Target Information
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Gut homing receptor beta subunit; integrin beta 7 subunit; Integrin beta-7; Integrin beta-P; integrin, beta 7; M290 IEL antigen
Gene Aliases: ITGB7; Ly69
UniProt ID: (Human) P26010, (Mouse) P26011
Entrez Gene ID: (Human) 3695, (Rat) 25713, (Mouse) 16421
cell-matrix adhesion involved in ameboidal cell migration
cell-matrix adhesion
integrin-mediated signaling pathway
multicellular organism development
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
receptor clustering
leukocyte migration
leukocyte tethering or rolling
T cell migration
cell adhesion
extracellular matrix organization
viral entry into host cell
regulation of immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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